EPCT-20. TECHNICAL FEASIBILITY SODIUM (23NA) MRI OF PEDIATRIC GLIOMAS

Pediatric glioma response to novel targeted therapy can be heterogeneous on conventional proton ((1)H) MRI. Sodium concentration, as measured with (23)Na MRI in adult brain tumors can provide complementary assessment of tumor proliferation to conventional MRI. However, (23)Na MRI pediatric brain tumor studies are lacking. Determine the technical feasibility of performing sodium(23)Na MRI on pediatric glioma patients. Prospective study of an immunotherapy trial for newly diagnosed and recurrent gliomas (high-grade gliomas, low-grade gliomas, brainstem gliomas) in which participants were imaged with (23)Na MRI at 3.0 Tesla. The participants (n=26, 14 males) with median age of 11 years (range = 4–23 years of age) were prospectively evaluated with sodium. (23)Na MRI is technically feasible in the pediatric population and can distinguish different types of pediatric gliomas at baseline.