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Real-time monitoring of crystallization from solution by using an interdigitated array electrode sensor
Monitoring crystallization events in real-time is challenging but crucial for understanding the molecular dynamics associated with nucleation and crystal growth, some of nature's most ubiquitous phenomena. Recent observations have suggested that the traditional nucleation model, which describes...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168339/ https://www.ncbi.nlm.nih.gov/pubmed/33908438 http://dx.doi.org/10.1039/d0nh00685h |
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author | Tong, Jincheng Doumbia, Amadou Turner, Michael L. Casiraghi, Cinzia |
author_facet | Tong, Jincheng Doumbia, Amadou Turner, Michael L. Casiraghi, Cinzia |
author_sort | Tong, Jincheng |
collection | PubMed |
description | Monitoring crystallization events in real-time is challenging but crucial for understanding the molecular dynamics associated with nucleation and crystal growth, some of nature's most ubiquitous phenomena. Recent observations have suggested that the traditional nucleation model, which describes the nucleus having already the final crystal structure, may not be valid. It appears that the molecular assembly can range during nucleation from crystalline to partially ordered to totally amorphous phases, and can change its structure during the crystallization process. Therefore, it is of critical importance to develop methods that are able to provide real-time monitoring of the molecular interactions with high temporal resolution. Here, we demonstrate that a simple and scalable approach based on interdigitated electrode array sensors (IESs) is able to provide insights on the dynamics of the crystallization process with a temporal resolution of 15 ms. |
format | Online Article Text |
id | pubmed-8168339 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-81683392021-06-11 Real-time monitoring of crystallization from solution by using an interdigitated array electrode sensor Tong, Jincheng Doumbia, Amadou Turner, Michael L. Casiraghi, Cinzia Nanoscale Horiz Chemistry Monitoring crystallization events in real-time is challenging but crucial for understanding the molecular dynamics associated with nucleation and crystal growth, some of nature's most ubiquitous phenomena. Recent observations have suggested that the traditional nucleation model, which describes the nucleus having already the final crystal structure, may not be valid. It appears that the molecular assembly can range during nucleation from crystalline to partially ordered to totally amorphous phases, and can change its structure during the crystallization process. Therefore, it is of critical importance to develop methods that are able to provide real-time monitoring of the molecular interactions with high temporal resolution. Here, we demonstrate that a simple and scalable approach based on interdigitated electrode array sensors (IESs) is able to provide insights on the dynamics of the crystallization process with a temporal resolution of 15 ms. The Royal Society of Chemistry 2021-04-21 /pmc/articles/PMC8168339/ /pubmed/33908438 http://dx.doi.org/10.1039/d0nh00685h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Tong, Jincheng Doumbia, Amadou Turner, Michael L. Casiraghi, Cinzia Real-time monitoring of crystallization from solution by using an interdigitated array electrode sensor |
title | Real-time monitoring of crystallization from solution by using an interdigitated array electrode sensor |
title_full | Real-time monitoring of crystallization from solution by using an interdigitated array electrode sensor |
title_fullStr | Real-time monitoring of crystallization from solution by using an interdigitated array electrode sensor |
title_full_unstemmed | Real-time monitoring of crystallization from solution by using an interdigitated array electrode sensor |
title_short | Real-time monitoring of crystallization from solution by using an interdigitated array electrode sensor |
title_sort | real-time monitoring of crystallization from solution by using an interdigitated array electrode sensor |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168339/ https://www.ncbi.nlm.nih.gov/pubmed/33908438 http://dx.doi.org/10.1039/d0nh00685h |
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