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Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs

Several genome-wide CRISPR knockout screens have been conducted to identify host factors regulating SARS-CoV-2 replication, but the models used have often relied on overexpression of ACE2 receptor. Additionally, such screens have yet to identify the protease TMPRSS2, known to be important for viral...

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Detalles Bibliográficos
Autores principales:	Rebendenne, Antoine, Roy, Priyanka, Bonaventure, Boris, Chaves, Valadão Ana Luiza, Desmarets, Lowiese, Rouillé, Yves, Tauziet, Marine, Arnaud-Arnould, Mary, Giovannini, Donatella, Lee, Yenarae, DeWeirdt, Peter, Hegde, Mudra, Garcia de, Gracia Francisco, McKellar, Joe, Wencker, Mélanie, Dubuisson, Jean, Belouzard, Sandrine, Moncorgé, Olivier, Doench, John G., Goujon, Caroline
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Journal Experts 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168385/ https://www.ncbi.nlm.nih.gov/pubmed/34075371 http://dx.doi.org/10.21203/rs.3.rs-555275/v1

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