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High SAA1 Expression Predicts Advanced Tumors in Renal Cancer

Renal cell carcinoma (RCC) is the most frequent malignant tumor of the kidney. 30% of patients with RCC are diagnosed at an advanced stage. Clear cell renal cell carcinoma (ccRCC) is the most common pathological subtype of RCC. Currently, advanced ccRCC lacks reliable diagnostic and prognostic marke...

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Autores principales: Li, Sen, Cheng, Yongbiao, Cheng, Gong, Xu, Tianbo, Ye, Yuzhong, Miu, Qi, Cao, Qi, Yang, Xiong, Ruan, Hailong, Zhang, Xiaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168437/
https://www.ncbi.nlm.nih.gov/pubmed/34084746
http://dx.doi.org/10.3389/fonc.2021.649761
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author Li, Sen
Cheng, Yongbiao
Cheng, Gong
Xu, Tianbo
Ye, Yuzhong
Miu, Qi
Cao, Qi
Yang, Xiong
Ruan, Hailong
Zhang, Xiaoping
author_facet Li, Sen
Cheng, Yongbiao
Cheng, Gong
Xu, Tianbo
Ye, Yuzhong
Miu, Qi
Cao, Qi
Yang, Xiong
Ruan, Hailong
Zhang, Xiaoping
author_sort Li, Sen
collection PubMed
description Renal cell carcinoma (RCC) is the most frequent malignant tumor of the kidney. 30% of patients with RCC are diagnosed at an advanced stage. Clear cell renal cell carcinoma (ccRCC) is the most common pathological subtype of RCC. Currently, advanced ccRCC lacks reliable diagnostic and prognostic markers. We explored the potential of SAA1 as a diagnostic and prognostic marker for advanced ccRCC. In this study, we mined and analyzed the public cancer databases (TCGA, UALCAN and GEPIA) to conclude that SAA1 was up-regulated at mRNA and protein levels in advanced ccRCC. We further found that hypomethylation of SAA1 promoter region was responsible for its high expression in ccRCC. Receiver operating characteristic curve (ROC) indicated that high SAA1 levels could distinguish advanced ccRCC patients from normal subjects (p < 0.0001). Kaplan-Meier curve analysis showed that high SAA1 levels predicted poor overall survival time (p < 0.0001) and poor disease-free survival time (p = 0.0003). Finally, the functional roles of SAA1 were examined using a si-SAA1 knockdown method in RCC cell lines. Our results suggest that SAA1 may possess the potential to serve as a diagnostic and prognostic biomarker for advanced ccRCC patients. Moreover, targeting SAA1 may represent as a novel therapeutic target for advanced ccRCC patients.
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spelling pubmed-81684372021-06-02 High SAA1 Expression Predicts Advanced Tumors in Renal Cancer Li, Sen Cheng, Yongbiao Cheng, Gong Xu, Tianbo Ye, Yuzhong Miu, Qi Cao, Qi Yang, Xiong Ruan, Hailong Zhang, Xiaoping Front Oncol Oncology Renal cell carcinoma (RCC) is the most frequent malignant tumor of the kidney. 30% of patients with RCC are diagnosed at an advanced stage. Clear cell renal cell carcinoma (ccRCC) is the most common pathological subtype of RCC. Currently, advanced ccRCC lacks reliable diagnostic and prognostic markers. We explored the potential of SAA1 as a diagnostic and prognostic marker for advanced ccRCC. In this study, we mined and analyzed the public cancer databases (TCGA, UALCAN and GEPIA) to conclude that SAA1 was up-regulated at mRNA and protein levels in advanced ccRCC. We further found that hypomethylation of SAA1 promoter region was responsible for its high expression in ccRCC. Receiver operating characteristic curve (ROC) indicated that high SAA1 levels could distinguish advanced ccRCC patients from normal subjects (p < 0.0001). Kaplan-Meier curve analysis showed that high SAA1 levels predicted poor overall survival time (p < 0.0001) and poor disease-free survival time (p = 0.0003). Finally, the functional roles of SAA1 were examined using a si-SAA1 knockdown method in RCC cell lines. Our results suggest that SAA1 may possess the potential to serve as a diagnostic and prognostic biomarker for advanced ccRCC patients. Moreover, targeting SAA1 may represent as a novel therapeutic target for advanced ccRCC patients. Frontiers Media S.A. 2021-05-18 /pmc/articles/PMC8168437/ /pubmed/34084746 http://dx.doi.org/10.3389/fonc.2021.649761 Text en Copyright © 2021 Li, Cheng, Cheng, Xu, Ye, Miu, Cao, Yang, Ruan and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Li, Sen
Cheng, Yongbiao
Cheng, Gong
Xu, Tianbo
Ye, Yuzhong
Miu, Qi
Cao, Qi
Yang, Xiong
Ruan, Hailong
Zhang, Xiaoping
High SAA1 Expression Predicts Advanced Tumors in Renal Cancer
title High SAA1 Expression Predicts Advanced Tumors in Renal Cancer
title_full High SAA1 Expression Predicts Advanced Tumors in Renal Cancer
title_fullStr High SAA1 Expression Predicts Advanced Tumors in Renal Cancer
title_full_unstemmed High SAA1 Expression Predicts Advanced Tumors in Renal Cancer
title_short High SAA1 Expression Predicts Advanced Tumors in Renal Cancer
title_sort high saa1 expression predicts advanced tumors in renal cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168437/
https://www.ncbi.nlm.nih.gov/pubmed/34084746
http://dx.doi.org/10.3389/fonc.2021.649761
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