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Ethacrynic Acid Enhances the Antitumor Effects of Afatinib in EGFR/T790M-Mutated NSCLC by Inhibiting WNT/Beta-Catenin Pathway Activation

Background. Despite afatinib as a new first-line treatment for EGFR L858R and exon 19 deletion or other rare EGFR-mutation patients, the acquired resistance or toxic effects associated with it limited its use clinically. The controlling of acquired resistance or optimization of the afatinib dosage i...

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Detalles Bibliográficos
Autores principales:	Zhang, Xuehui, Huang, Chaoyuan, Cui, Biyu, Pang, Yebin, Liang, Rong, Luo, Xiaoling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168479/ https://www.ncbi.nlm.nih.gov/pubmed/34122668 http://dx.doi.org/10.1155/2021/5530673

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