A frequent nonsense mutation in exon 1 across certain HLA-A and HLA-B alleles in leukocytes of patients with acquired aplastic anemia

Leukocytes that lack expression of HLA alleles are frequently detected in patients with acquired aplastic anemia (AA) who respond to immunosuppressive therapy, although the exact mechanisms underlying the HLA loss and HLA allele repertoire likely to acquire loss-of-function mutations are unknown. We...

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Detalles Bibliográficos
Autores principales: Mizumaki, Hiroki, Hosomichi, Kazuyoshi, Hosokawa, Kohei, Yoroidaka, Takeshi, Imi, Tatsuya, Zaimoku, Yoshitaka, Katagiri, Takamasa, Nguyen, Mai Anh Thi, Tran, Dung Cao, Elbadry, Mahmoud Ibrahim Yousef, Chonabayashi, Kazuhisa, Yoshida, Yoshinori, Takamatsu, Hiroyuki, Ozawa, Tatsuhiko, Azuma, Fumihiro, Kishi, Hiroyuki, Fujii, Yoichi, Ogawa, Seishi, Tajima, Atsushi, Nakao, Shinji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168509/
https://www.ncbi.nlm.nih.gov/pubmed/32439725
http://dx.doi.org/10.3324/haematol.2020.247809

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