Fibrinogen interaction with complement C3: a potential therapeutic target to reduce thrombosis risk

Complement C3 binds fibrinogen and compromises fibrin clot lysis, thereby enhancing the risk of thrombosis. We investigated the role of the fibrinogen-C3 interaction as a novel therapeutic target to reduce thrombosis risk by analyzing: (i) consistency in the fibrinolytic properties of C3; (ii) bindi...

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Detalles Bibliográficos
Autores principales: King, Rhodri J., Schuett, Katharina, Tiede, Christian, Jankowski, Vera, John, Vicky, Trehan, Abhi, Simmons, Katie, Ponnambalam, Sreenivasan, Storey, Robert F., Fishwick, Colin W.G., McPherson, Michael J., Tomlinson, Darren C., Ajjan, Ramzi A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168514/
https://www.ncbi.nlm.nih.gov/pubmed/32354869
http://dx.doi.org/10.3324/haematol.2019.239558

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168514/
https://www.ncbi.nlm.nih.gov/pubmed/32354869
http://dx.doi.org/10.3324/haematol.2019.239558

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