Features and mechanisms of canonical and noncanonical genomic imprinting

Genomic imprinting is the monoallelic expression of a gene based on parent of origin and is a consequence of differential epigenetic marking between the male and female germlines. Canonically, genomic imprinting is mediated by allelic DNA methylation. However, recently it has been shown that materna...

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Autores principales: Hanna, Courtney W., Kelsey, Gavin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168557/
https://www.ncbi.nlm.nih.gov/pubmed/34074696
http://dx.doi.org/10.1101/gad.348422.121
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author Hanna, Courtney W.
Kelsey, Gavin
author_facet Hanna, Courtney W.
Kelsey, Gavin
author_sort Hanna, Courtney W.
collection PubMed
description Genomic imprinting is the monoallelic expression of a gene based on parent of origin and is a consequence of differential epigenetic marking between the male and female germlines. Canonically, genomic imprinting is mediated by allelic DNA methylation. However, recently it has been shown that maternal H3K27me3 can result in DNA methylation-independent imprinting, termed “noncanonical imprinting.” In this review, we compare and contrast what is currently known about the underlying mechanisms, the role of endogenous retroviral elements, and the conservation of canonical and noncanonical genomic imprinting.
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spelling pubmed-81685572021-06-14 Features and mechanisms of canonical and noncanonical genomic imprinting Hanna, Courtney W. Kelsey, Gavin Genes Dev Review Genomic imprinting is the monoallelic expression of a gene based on parent of origin and is a consequence of differential epigenetic marking between the male and female germlines. Canonically, genomic imprinting is mediated by allelic DNA methylation. However, recently it has been shown that maternal H3K27me3 can result in DNA methylation-independent imprinting, termed “noncanonical imprinting.” In this review, we compare and contrast what is currently known about the underlying mechanisms, the role of endogenous retroviral elements, and the conservation of canonical and noncanonical genomic imprinting. Cold Spring Harbor Laboratory Press 2021-06 /pmc/articles/PMC8168557/ /pubmed/34074696 http://dx.doi.org/10.1101/gad.348422.121 Text en © 2021 Hanna and Kelsey; Published by Cold Spring Harbor Laboratory Press https://creativecommons.org/licenses/by/4.0/This article, published in Genes & Development, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Hanna, Courtney W.
Kelsey, Gavin
Features and mechanisms of canonical and noncanonical genomic imprinting
title Features and mechanisms of canonical and noncanonical genomic imprinting
title_full Features and mechanisms of canonical and noncanonical genomic imprinting
title_fullStr Features and mechanisms of canonical and noncanonical genomic imprinting
title_full_unstemmed Features and mechanisms of canonical and noncanonical genomic imprinting
title_short Features and mechanisms of canonical and noncanonical genomic imprinting
title_sort features and mechanisms of canonical and noncanonical genomic imprinting
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168557/
https://www.ncbi.nlm.nih.gov/pubmed/34074696
http://dx.doi.org/10.1101/gad.348422.121
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