ASCL1 represses a SOX9(+) neural crest stem-like state in small cell lung cancer

ASCL1 is a neuroendocrine lineage-specific oncogenic driver of small cell lung cancer (SCLC), highly expressed in a significant fraction of tumors. However, ∼25% of human SCLC are ASCL1-low and associated with low neuroendocrine fate and high MYC expression. Using genetically engineered mouse models...

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Detalles Bibliográficos
Autores principales: Olsen, Rachelle R., Ireland, Abbie S., Kastner, David W., Groves, Sarah M., Spainhower, Kyle B., Pozo, Karine, Kelenis, Demetra P., Whitney, Christopher P., Guthrie, Matthew R., Wait, Sarah J., Soltero, Danny, Witt, Benjamin L., Quaranta, Vito, Johnson, Jane E., Oliver, Trudy G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168563/
https://www.ncbi.nlm.nih.gov/pubmed/34016693
http://dx.doi.org/10.1101/gad.348295.121

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