Purifying selection on noncoding deletions of human regulatory loci detected using their cellular pleiotropy

Genomic deletions provide a powerful loss-of-function model in noncoding regions to assess the role of purifying selection on genetic variation. Regulatory element function is characterized by nonuniform tissue and cell type activity, necessarily linking the study of fitness consequences from regula...

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Detalles Bibliográficos
Autores principales: Radke, David W., Sul, Jae Hoon, Balick, Daniel J., Akle, Sebastian, Green, Robert C., Sunyaev, Shamil R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168579/
https://www.ncbi.nlm.nih.gov/pubmed/33963077
http://dx.doi.org/10.1101/gr.275263.121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168579/
https://www.ncbi.nlm.nih.gov/pubmed/33963077
http://dx.doi.org/10.1101/gr.275263.121

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