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Multiple cerebral hemorrhages in sepsis-disseminated intravascular coagulation versus septic embolism: An image report

BACKGROUND: Septic emboli are commonly attributed to infective endocarditis and can present with a variety of symptoms including altered mental status and focal neurological deficits. Here, we reviewed images of septic emboli with hemorrhagic conversion in a patient with sepsis and a psoas abscess....

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Autores principales: Akel, Omar, Raju, Bharath, Suresh, Sumatha Channapatna, Jumah, Fareed, Gupta, Gaurav, Nanda, Anil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Scientific Scholar 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168679/
https://www.ncbi.nlm.nih.gov/pubmed/34084613
http://dx.doi.org/10.25259/SNI_810_2020
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author Akel, Omar
Raju, Bharath
Suresh, Sumatha Channapatna
Jumah, Fareed
Gupta, Gaurav
Nanda, Anil
author_facet Akel, Omar
Raju, Bharath
Suresh, Sumatha Channapatna
Jumah, Fareed
Gupta, Gaurav
Nanda, Anil
author_sort Akel, Omar
collection PubMed
description BACKGROUND: Septic emboli are commonly attributed to infective endocarditis and can present with a variety of symptoms including altered mental status and focal neurological deficits. Here, we reviewed images of septic emboli with hemorrhagic conversion in a patient with sepsis and a psoas abscess. We aim to show the classical image findings in septic embolism to brain, which is sparsely described in literature and the report differentiates the septic embolism from disseminated intravascular coagulation which can present with almost identical image findings. CASE DESCRIPTION: A 53-year-old male patient who was operated on for a right inguinal hernia developed a postoperative wound infection 2 weeks after surgery and was started on IV antibiotics. Despite medical management, his infection did not improve, prompting a computed tomography (CT) scan which revealed a psoas abscess. The abscess was drained, and antibiotics continued. A few days later, he developed altered sensorium prompting a head CT which revealed septic emboli and hemorrhage at the gray-white junction. Cultures grew multidrug-resistant Escherichia coli; the patient was treated with IV tigecycline and improved over the following 4 weeks. CONCLUSION: In patients with a known ongoing infectious process with hemodynamic stability who develop altered mental status in the setting of a normal coagulation profile, D-dimer, positive blood cultures, and absent signs of multiorgan failure, a diagnosis of septic emboli should be entertained. Although CT can reveal macrobleeds, MRI is more sensitive in confirming cerebral microbleeds. Thus, patients in sepsis with unexplained altered sensorium should undergo an MRI of the brain to rule out septic emboli and microbleeds.
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spelling pubmed-81686792021-06-02 Multiple cerebral hemorrhages in sepsis-disseminated intravascular coagulation versus septic embolism: An image report Akel, Omar Raju, Bharath Suresh, Sumatha Channapatna Jumah, Fareed Gupta, Gaurav Nanda, Anil Surg Neurol Int Image Report BACKGROUND: Septic emboli are commonly attributed to infective endocarditis and can present with a variety of symptoms including altered mental status and focal neurological deficits. Here, we reviewed images of septic emboli with hemorrhagic conversion in a patient with sepsis and a psoas abscess. We aim to show the classical image findings in septic embolism to brain, which is sparsely described in literature and the report differentiates the septic embolism from disseminated intravascular coagulation which can present with almost identical image findings. CASE DESCRIPTION: A 53-year-old male patient who was operated on for a right inguinal hernia developed a postoperative wound infection 2 weeks after surgery and was started on IV antibiotics. Despite medical management, his infection did not improve, prompting a computed tomography (CT) scan which revealed a psoas abscess. The abscess was drained, and antibiotics continued. A few days later, he developed altered sensorium prompting a head CT which revealed septic emboli and hemorrhage at the gray-white junction. Cultures grew multidrug-resistant Escherichia coli; the patient was treated with IV tigecycline and improved over the following 4 weeks. CONCLUSION: In patients with a known ongoing infectious process with hemodynamic stability who develop altered mental status in the setting of a normal coagulation profile, D-dimer, positive blood cultures, and absent signs of multiorgan failure, a diagnosis of septic emboli should be entertained. Although CT can reveal macrobleeds, MRI is more sensitive in confirming cerebral microbleeds. Thus, patients in sepsis with unexplained altered sensorium should undergo an MRI of the brain to rule out septic emboli and microbleeds. Scientific Scholar 2021-04-26 /pmc/articles/PMC8168679/ /pubmed/34084613 http://dx.doi.org/10.25259/SNI_810_2020 Text en Copyright: © 2021 Surgical Neurology International https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Image Report
Akel, Omar
Raju, Bharath
Suresh, Sumatha Channapatna
Jumah, Fareed
Gupta, Gaurav
Nanda, Anil
Multiple cerebral hemorrhages in sepsis-disseminated intravascular coagulation versus septic embolism: An image report
title Multiple cerebral hemorrhages in sepsis-disseminated intravascular coagulation versus septic embolism: An image report
title_full Multiple cerebral hemorrhages in sepsis-disseminated intravascular coagulation versus septic embolism: An image report
title_fullStr Multiple cerebral hemorrhages in sepsis-disseminated intravascular coagulation versus septic embolism: An image report
title_full_unstemmed Multiple cerebral hemorrhages in sepsis-disseminated intravascular coagulation versus septic embolism: An image report
title_short Multiple cerebral hemorrhages in sepsis-disseminated intravascular coagulation versus septic embolism: An image report
title_sort multiple cerebral hemorrhages in sepsis-disseminated intravascular coagulation versus septic embolism: an image report
topic Image Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168679/
https://www.ncbi.nlm.nih.gov/pubmed/34084613
http://dx.doi.org/10.25259/SNI_810_2020
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