Programmed cell death 1 ligand (PD-L1) on T cells generates Treg suppression from memory

A recent study shows that programmed cell death 1 ligand (PD-L1) on activated T cells promotes their conversion to suppressive inducible regulatory T cells (iTregs), preferentially from among memory T cells. This new mechanism may normally protect against autoimmunity but is dysregulated in rheumato...

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Detalles Bibliográficos
Autores principales: Kazanova, Alexandra, Rudd, Christopher E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Primer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168839/
https://www.ncbi.nlm.nih.gov/pubmed/34010274
http://dx.doi.org/10.1371/journal.pbio.3001272
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author Kazanova, Alexandra
Rudd, Christopher E.
author_facet Kazanova, Alexandra
Rudd, Christopher E.
author_sort Kazanova, Alexandra
collection PubMed
description A recent study shows that programmed cell death 1 ligand (PD-L1) on activated T cells promotes their conversion to suppressive inducible regulatory T cells (iTregs), preferentially from among memory T cells. This new mechanism may normally protect against autoimmunity but is dysregulated in rheumatoid arthritis.
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spelling pubmed-81688392021-06-11 Programmed cell death 1 ligand (PD-L1) on T cells generates Treg suppression from memory Kazanova, Alexandra Rudd, Christopher E. PLoS Biol Primer A recent study shows that programmed cell death 1 ligand (PD-L1) on activated T cells promotes their conversion to suppressive inducible regulatory T cells (iTregs), preferentially from among memory T cells. This new mechanism may normally protect against autoimmunity but is dysregulated in rheumatoid arthritis. Public Library of Science 2021-05-19 /pmc/articles/PMC8168839/ /pubmed/34010274 http://dx.doi.org/10.1371/journal.pbio.3001272 Text en © 2021 Kazanova, Rudd https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Primer
Kazanova, Alexandra
Rudd, Christopher E.
Programmed cell death 1 ligand (PD-L1) on T cells generates Treg suppression from memory
title Programmed cell death 1 ligand (PD-L1) on T cells generates Treg suppression from memory
title_full Programmed cell death 1 ligand (PD-L1) on T cells generates Treg suppression from memory
title_fullStr Programmed cell death 1 ligand (PD-L1) on T cells generates Treg suppression from memory
title_full_unstemmed Programmed cell death 1 ligand (PD-L1) on T cells generates Treg suppression from memory
title_short Programmed cell death 1 ligand (PD-L1) on T cells generates Treg suppression from memory
title_sort programmed cell death 1 ligand (pd-l1) on t cells generates treg suppression from memory
topic Primer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168839/
https://www.ncbi.nlm.nih.gov/pubmed/34010274
http://dx.doi.org/10.1371/journal.pbio.3001272
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