Metastatic Renal Cell Carcinoma to the Cerebrum in a Patient With Lynch Syndrome: A Case Report

Hereditary nonpolyposis colorectal cancer (HNPCC) or Lynch syndrome is an autosomal-dominant genetic disorder of DNA mismatch repair associated with many forms of cancer, especially colorectal and including renal cell. In this report, we present a case of a patient with a known history of HNPCC whose first presentation of renal cell carcinoma (RCC) was associated with a symptomatic intracranial lesion. After intracranial imaging, resection, and pathologic examination, the lesion was revealed to be of RCC origin. Further imaging revealed primary RCC. HNPCC may present with neurologic symptoms prior to the diagnosis of primary cancer, and lower levels of suspicion for intracranial lesions may be required to properly treat this patient population.