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Mini-Review: PDPK1 (3-phosphoinositide dependent protein kinase-1), An Emerging Cancer Stem Cell Target

Cancer stem cells (CSCs) are subpopulations of tumor cells that possess abilities for self-renewal, differentiation, and tumor initiation. These rare but therapy-recalcitrant cells are assumed to repopulate tumors following administration of systemic chemotherapy driving therapy failure, tumor recur...

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Detalles Bibliográficos
Autores principales: Domrachev, Bogdan, Singh, Sitanshu, Li, Dandan, Rudloff, Udo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168947/
https://www.ncbi.nlm.nih.gov/pubmed/34079928
http://dx.doi.org/10.29245/2578-2967/2021/1.1194
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author Domrachev, Bogdan
Singh, Sitanshu
Li, Dandan
Rudloff, Udo
author_facet Domrachev, Bogdan
Singh, Sitanshu
Li, Dandan
Rudloff, Udo
author_sort Domrachev, Bogdan
collection PubMed
description Cancer stem cells (CSCs) are subpopulations of tumor cells that possess abilities for self-renewal, differentiation, and tumor initiation. These rare but therapy-recalcitrant cells are assumed to repopulate tumors following administration of systemic chemotherapy driving therapy failure, tumor recurrence, and disease progression. In early clinical trials, anti-CSC therapies have found limited success to-date possibly due to the inherent heterogeneity and plasticity of CSCs and the incomplete characterization of essential CSC targets. Here, we review the role of 3-phosphoinositide dependent protein kinase-1 (PDPK1) as an emerging CSC target. While most previous studies have relied on CSC models which are based on lineage and tissue-specific marker profiles to define the relationships between putative target and CSC traits, this review discusses PDPK1 and its role in CSC biology with an emphasis on CSC systems which are based on proposed function like label-retaining cancer cells (LRCCs).
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spelling pubmed-81689472021-06-01 Mini-Review: PDPK1 (3-phosphoinositide dependent protein kinase-1), An Emerging Cancer Stem Cell Target Domrachev, Bogdan Singh, Sitanshu Li, Dandan Rudloff, Udo J Cancer Treatment Diagn Article Cancer stem cells (CSCs) are subpopulations of tumor cells that possess abilities for self-renewal, differentiation, and tumor initiation. These rare but therapy-recalcitrant cells are assumed to repopulate tumors following administration of systemic chemotherapy driving therapy failure, tumor recurrence, and disease progression. In early clinical trials, anti-CSC therapies have found limited success to-date possibly due to the inherent heterogeneity and plasticity of CSCs and the incomplete characterization of essential CSC targets. Here, we review the role of 3-phosphoinositide dependent protein kinase-1 (PDPK1) as an emerging CSC target. While most previous studies have relied on CSC models which are based on lineage and tissue-specific marker profiles to define the relationships between putative target and CSC traits, this review discusses PDPK1 and its role in CSC biology with an emphasis on CSC systems which are based on proposed function like label-retaining cancer cells (LRCCs). 2021-04-30 /pmc/articles/PMC8168947/ /pubmed/34079928 http://dx.doi.org/10.29245/2578-2967/2021/1.1194 Text en https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 International License.
spellingShingle Article
Domrachev, Bogdan
Singh, Sitanshu
Li, Dandan
Rudloff, Udo
Mini-Review: PDPK1 (3-phosphoinositide dependent protein kinase-1), An Emerging Cancer Stem Cell Target
title Mini-Review: PDPK1 (3-phosphoinositide dependent protein kinase-1), An Emerging Cancer Stem Cell Target
title_full Mini-Review: PDPK1 (3-phosphoinositide dependent protein kinase-1), An Emerging Cancer Stem Cell Target
title_fullStr Mini-Review: PDPK1 (3-phosphoinositide dependent protein kinase-1), An Emerging Cancer Stem Cell Target
title_full_unstemmed Mini-Review: PDPK1 (3-phosphoinositide dependent protein kinase-1), An Emerging Cancer Stem Cell Target
title_short Mini-Review: PDPK1 (3-phosphoinositide dependent protein kinase-1), An Emerging Cancer Stem Cell Target
title_sort mini-review: pdpk1 (3-phosphoinositide dependent protein kinase-1), an emerging cancer stem cell target
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168947/
https://www.ncbi.nlm.nih.gov/pubmed/34079928
http://dx.doi.org/10.29245/2578-2967/2021/1.1194
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