NLRP1 variant M1184V decreases inflammasome activation in the context of DPP9 inhibition and asthma severity

BACKGROUND: NLRP1 is an innate immune sensor that can form cytoplasmic inflammasome complexes. Polymorphisms in NLRP1 are linked to asthma; however, there is currently no functional or mechanistic explanation for this. OBJECTIVE: We sought to clarify the role of NLRP1 in asthma pathogenesis. METHODS...

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Detalles Bibliográficos
Autores principales: Moecking, Jonas, Laohamonthonkul, Pawat, Chalker, Katelyn, White, Marquitta J., Harapas, Cassandra R., Yu, Chien-Hsiung, Davidson, Sophia, Hrovat-Schaale, Katja, Hu, Donglei, Eng, Celeste, Huntsman, Scott, Calleja, Dale J., Horvat, Jay C., Hansbro, Phil M., O’Donoghue, Robert J.J., Ting, Jenny P., Burchard, Esteban G., Geyer, Matthias, Gerlic, Motti, Masters, Seth L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mosby 2021
Materias:
Asthma and Lower Airway Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168955/
https://www.ncbi.nlm.nih.gov/pubmed/33378691
http://dx.doi.org/10.1016/j.jaci.2020.12.636

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