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Management of Persistent Corneal Epithelial Defects with Human Amniotic Membrane-derived Dry Matrix
OBJECTIVE: To report the outcomes of using human amniotic membrane-derived dry matrix (AMDDM) in the management of persistent corneal epithelial defects (PEDs) of various etiologies. METHODS: A cohort study of 84 patients age range 7 to 92 years with 93 PEDs were treated with AMDDM (Omnigen(®) using...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169046/ https://www.ncbi.nlm.nih.gov/pubmed/34093006 http://dx.doi.org/10.2147/OPTH.S299141 |
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author | Maqsood, Sundas Elsawah, Kareem Dhillon, Navpreet Soliman, Shady Laginaf, Masara Lodhia, Vaishali Lake, Damian Hamada, Samer Elalfy, Mohamed |
author_facet | Maqsood, Sundas Elsawah, Kareem Dhillon, Navpreet Soliman, Shady Laginaf, Masara Lodhia, Vaishali Lake, Damian Hamada, Samer Elalfy, Mohamed |
author_sort | Maqsood, Sundas |
collection | PubMed |
description | OBJECTIVE: To report the outcomes of using human amniotic membrane-derived dry matrix (AMDDM) in the management of persistent corneal epithelial defects (PEDs) of various etiologies. METHODS: A cohort study of 84 patients age range 7 to 92 years with 93 PEDs were treated with AMDDM (Omnigen(®) using OmniLenz(®) at two centers (Queen Victoria Hospital and Maidstone Hospital) in the UK. The main outcome measures were healing response of PED and time to heal after application of AMDDM. RESULTS: A total of 106 applications of AMDDM were recorded for 81 patients (52 males, 29 females) with a spectrum of different etiologies. Fifty-eight percent of the eyes showed complete healing, and 28% showed partial decrease of the size of PEDs with average treatment length recorded as 22.4±12.3 days. In patients with limbal stem cell deficiency (n=44; aniridia=12, chemical injury=9, Stevens–Johnson syndrome=10), 50% of PEDs showed complete healing and 27% showed partial healing. In patients with microbial keratitis (n=21) (bacterial: 13, fungal: 4, herpetic: 3, acanthamoeba: 1) 57% of PEDs showed complete healing and 33% were partially healed. In patients with keratoplasty (n=16), 56% of PEDs showed complete healing and 31% were partially healed. Vision remained stable in 59% and improved in 27% of the study the population. CONCLUSION: AMDDM can be easily applied in the clinical setting and has demonstrated its efficiency as a new tool to treat persistent epithelial defects. |
format | Online Article Text |
id | pubmed-8169046 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-81690462021-06-03 Management of Persistent Corneal Epithelial Defects with Human Amniotic Membrane-derived Dry Matrix Maqsood, Sundas Elsawah, Kareem Dhillon, Navpreet Soliman, Shady Laginaf, Masara Lodhia, Vaishali Lake, Damian Hamada, Samer Elalfy, Mohamed Clin Ophthalmol Original Research OBJECTIVE: To report the outcomes of using human amniotic membrane-derived dry matrix (AMDDM) in the management of persistent corneal epithelial defects (PEDs) of various etiologies. METHODS: A cohort study of 84 patients age range 7 to 92 years with 93 PEDs were treated with AMDDM (Omnigen(®) using OmniLenz(®) at two centers (Queen Victoria Hospital and Maidstone Hospital) in the UK. The main outcome measures were healing response of PED and time to heal after application of AMDDM. RESULTS: A total of 106 applications of AMDDM were recorded for 81 patients (52 males, 29 females) with a spectrum of different etiologies. Fifty-eight percent of the eyes showed complete healing, and 28% showed partial decrease of the size of PEDs with average treatment length recorded as 22.4±12.3 days. In patients with limbal stem cell deficiency (n=44; aniridia=12, chemical injury=9, Stevens–Johnson syndrome=10), 50% of PEDs showed complete healing and 27% showed partial healing. In patients with microbial keratitis (n=21) (bacterial: 13, fungal: 4, herpetic: 3, acanthamoeba: 1) 57% of PEDs showed complete healing and 33% were partially healed. In patients with keratoplasty (n=16), 56% of PEDs showed complete healing and 31% were partially healed. Vision remained stable in 59% and improved in 27% of the study the population. CONCLUSION: AMDDM can be easily applied in the clinical setting and has demonstrated its efficiency as a new tool to treat persistent epithelial defects. Dove 2021-05-28 /pmc/articles/PMC8169046/ /pubmed/34093006 http://dx.doi.org/10.2147/OPTH.S299141 Text en © 2021 Maqsood et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Maqsood, Sundas Elsawah, Kareem Dhillon, Navpreet Soliman, Shady Laginaf, Masara Lodhia, Vaishali Lake, Damian Hamada, Samer Elalfy, Mohamed Management of Persistent Corneal Epithelial Defects with Human Amniotic Membrane-derived Dry Matrix |
title | Management of Persistent Corneal Epithelial Defects with Human Amniotic Membrane-derived Dry Matrix |
title_full | Management of Persistent Corneal Epithelial Defects with Human Amniotic Membrane-derived Dry Matrix |
title_fullStr | Management of Persistent Corneal Epithelial Defects with Human Amniotic Membrane-derived Dry Matrix |
title_full_unstemmed | Management of Persistent Corneal Epithelial Defects with Human Amniotic Membrane-derived Dry Matrix |
title_short | Management of Persistent Corneal Epithelial Defects with Human Amniotic Membrane-derived Dry Matrix |
title_sort | management of persistent corneal epithelial defects with human amniotic membrane-derived dry matrix |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169046/ https://www.ncbi.nlm.nih.gov/pubmed/34093006 http://dx.doi.org/10.2147/OPTH.S299141 |
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