Cargando…

Anticipation of temporally structured events in the brain

Learning about temporal structure is adaptive because it enables the generation of expectations. We examined how the brain uses experience in structured environments to anticipate upcoming events. During fMRI (functional magnetic resonance imaging), individuals watched a 90 s movie clip six times. U...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Caroline S, Aly, Mariam, Baldassano, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169103/
https://www.ncbi.nlm.nih.gov/pubmed/33884953
http://dx.doi.org/10.7554/eLife.64972
_version_ 1783701991350861824
author Lee, Caroline S
Aly, Mariam
Baldassano, Christopher
author_facet Lee, Caroline S
Aly, Mariam
Baldassano, Christopher
author_sort Lee, Caroline S
collection PubMed
description Learning about temporal structure is adaptive because it enables the generation of expectations. We examined how the brain uses experience in structured environments to anticipate upcoming events. During fMRI (functional magnetic resonance imaging), individuals watched a 90 s movie clip six times. Using a hidden Markov model applied to searchlights across the whole brain, we identified temporal shifts between activity patterns evoked by the first vs. repeated viewings of the movie clip. In many regions throughout the cortex, neural activity patterns for repeated viewings shifted to precede those of initial viewing by up to 15 s. This anticipation varied hierarchically in a posterior (less anticipation) to anterior (more anticipation) fashion. We also identified specific regions in which the timing of the brain’s event boundaries was related to those of human-labeled event boundaries, with the timing of this relationship shifting on repeated viewings. With repeated viewing, the brain’s event boundaries came to precede human-annotated boundaries by 1–4 s on average. Together, these results demonstrate a hierarchy of anticipatory signals in the human brain and link them to subjective experiences of events.
format Online
Article
Text
id pubmed-8169103
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher eLife Sciences Publications, Ltd
record_format MEDLINE/PubMed
spelling pubmed-81691032021-06-04 Anticipation of temporally structured events in the brain Lee, Caroline S Aly, Mariam Baldassano, Christopher eLife Neuroscience Learning about temporal structure is adaptive because it enables the generation of expectations. We examined how the brain uses experience in structured environments to anticipate upcoming events. During fMRI (functional magnetic resonance imaging), individuals watched a 90 s movie clip six times. Using a hidden Markov model applied to searchlights across the whole brain, we identified temporal shifts between activity patterns evoked by the first vs. repeated viewings of the movie clip. In many regions throughout the cortex, neural activity patterns for repeated viewings shifted to precede those of initial viewing by up to 15 s. This anticipation varied hierarchically in a posterior (less anticipation) to anterior (more anticipation) fashion. We also identified specific regions in which the timing of the brain’s event boundaries was related to those of human-labeled event boundaries, with the timing of this relationship shifting on repeated viewings. With repeated viewing, the brain’s event boundaries came to precede human-annotated boundaries by 1–4 s on average. Together, these results demonstrate a hierarchy of anticipatory signals in the human brain and link them to subjective experiences of events. eLife Sciences Publications, Ltd 2021-04-22 /pmc/articles/PMC8169103/ /pubmed/33884953 http://dx.doi.org/10.7554/eLife.64972 Text en © 2021, Lee et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Lee, Caroline S
Aly, Mariam
Baldassano, Christopher
Anticipation of temporally structured events in the brain
title Anticipation of temporally structured events in the brain
title_full Anticipation of temporally structured events in the brain
title_fullStr Anticipation of temporally structured events in the brain
title_full_unstemmed Anticipation of temporally structured events in the brain
title_short Anticipation of temporally structured events in the brain
title_sort anticipation of temporally structured events in the brain
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169103/
https://www.ncbi.nlm.nih.gov/pubmed/33884953
http://dx.doi.org/10.7554/eLife.64972
work_keys_str_mv AT leecarolines anticipationoftemporallystructuredeventsinthebrain
AT alymariam anticipationoftemporallystructuredeventsinthebrain
AT baldassanochristopher anticipationoftemporallystructuredeventsinthebrain