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Systematic screening of viral and human genetic variation identifies antiretroviral resistance and immune escape link

BACKGROUND: Considering the remaining threat of drug-resistantmutations (DRMs) to antiretroviral treatment (ART) efficacy, we investigated how the selective pressure of human leukocyte antigen (HLA)-restricted cytotoxic T lymphocytes drives certain DRMs’ emergence and retention. METHODS: We systemat...

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Detalles Bibliográficos
Autores principales:	Nguyen, Huyen, Thorball, Christian Wandell, Fellay, Jacques, Böni, Jürg, Yerly, Sabine, Perreau, Matthieu, Hirsch, Hans H, Kusejko, Katharina, Thurnheer, Maria Christine, Battegay, Manuel, Cavassini, Matthias, Kahlert, Christian R, Bernasconi, Enos, Günthard, Huldrych F, Kouyos, Roger D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Epidemiology and Global Health
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169104/ https://www.ncbi.nlm.nih.gov/pubmed/34061023 http://dx.doi.org/10.7554/eLife.67388

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