The Central Roles of Noncoding RNA in Estrogen-Dependent Female Reproductive System Tumors

The pathogenesis of ovarian and endometrial cancers is closely associated with estrogen-related pathways. These estrogen-dependent tumors seriously threaten the health and quality of life in women. Noncoding RNAs (ncRNAs) are defined as RNAs that do not encode proteins, including microRNAs (miRNAs)...

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Detalles Bibliográficos
Autores principales: Tu, Jiajie, Yang, Huan, Jiang, Lei, Chen, Yu, Yu Chen, Li, Zhe, Li, Lei, Zhang, Yuanyuan, Chen, Xiaochun, Chen, He, Yu, Zhiying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169271/
https://www.ncbi.nlm.nih.gov/pubmed/34122542
http://dx.doi.org/10.1155/2021/5572063
Descripción
Sumario:The pathogenesis of ovarian and endometrial cancers is closely associated with estrogen-related pathways. These estrogen-dependent tumors seriously threaten the health and quality of life in women. Noncoding RNAs (ncRNAs) are defined as RNAs that do not encode proteins, including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), both of which have been reported in estrogen-dependent female reproductive system tumors. This review systematically summarizes the role of ncRNAs in estrogen-dependent tumors and common patterns of regulatory mechanisms to explore their future research directions in tumor diagnosis, treatment, and prognosis. This may provide new ideas for the potential application of ncRNAs in estrogen-dependent female reproductive system tumors.

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