CD8‐positive peripheral T cell lymphoma in a patient following long‐term nivolumab for advanced lung adenocarcinoma: A case report

A 54‐year‐old male smoker presented with hemoptysis. Advanced lung adenocarcinoma, cT1cN3M1b, stage IVB, was diagnosed. Enlargement of multiple intraperitoneal and inguinal lymph nodes and peripheral atypical lymphocytosis appeared after 33 cycles of second‐line treatment with nivolumab, and a speci...

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Autores principales: Koda, Keigo, Toyoshima, Mikio, Yazawa, Shusuke, Fukada, Atsuki, Sugimura, Haruhiko, Suda, Takafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2021
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169286/
https://www.ncbi.nlm.nih.gov/pubmed/33939308
http://dx.doi.org/10.1111/1759-7714.13966
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author Koda, Keigo
Toyoshima, Mikio
Yazawa, Shusuke
Fukada, Atsuki
Sugimura, Haruhiko
Suda, Takafumi
author_facet Koda, Keigo
Toyoshima, Mikio
Yazawa, Shusuke
Fukada, Atsuki
Sugimura, Haruhiko
Suda, Takafumi
author_sort Koda, Keigo
collection PubMed
description A 54‐year‐old male smoker presented with hemoptysis. Advanced lung adenocarcinoma, cT1cN3M1b, stage IVB, was diagnosed. Enlargement of multiple intraperitoneal and inguinal lymph nodes and peripheral atypical lymphocytosis appeared after 33 cycles of second‐line treatment with nivolumab, and a specimen obtained by left inguinal lymph node biopsy showed peripheral T cell lymphoma (PTCL), not otherwise specified. Lymphoma cells expressed CD3+, CD8+, and CD56+, but not CD4+ or PD‐1. Despite systemic chemotherapy with cyclophosphamide, hydroxydaunorubicin, oncovin, and prednisolone, the patient died of PTCL 864 days after the initial visit. The possible relationship between treatment with immune checkpoint inhibitors (ICIs) and PTCL development is discussed here.
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spelling pubmed-81692862021-06-05 CD8‐positive peripheral T cell lymphoma in a patient following long‐term nivolumab for advanced lung adenocarcinoma: A case report Koda, Keigo Toyoshima, Mikio Yazawa, Shusuke Fukada, Atsuki Sugimura, Haruhiko Suda, Takafumi Thorac Cancer Case Reports A 54‐year‐old male smoker presented with hemoptysis. Advanced lung adenocarcinoma, cT1cN3M1b, stage IVB, was diagnosed. Enlargement of multiple intraperitoneal and inguinal lymph nodes and peripheral atypical lymphocytosis appeared after 33 cycles of second‐line treatment with nivolumab, and a specimen obtained by left inguinal lymph node biopsy showed peripheral T cell lymphoma (PTCL), not otherwise specified. Lymphoma cells expressed CD3+, CD8+, and CD56+, but not CD4+ or PD‐1. Despite systemic chemotherapy with cyclophosphamide, hydroxydaunorubicin, oncovin, and prednisolone, the patient died of PTCL 864 days after the initial visit. The possible relationship between treatment with immune checkpoint inhibitors (ICIs) and PTCL development is discussed here. John Wiley & Sons Australia, Ltd 2021-05-03 2021-06 /pmc/articles/PMC8169286/ /pubmed/33939308 http://dx.doi.org/10.1111/1759-7714.13966 Text en © 2021 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Koda, Keigo
Toyoshima, Mikio
Yazawa, Shusuke
Fukada, Atsuki
Sugimura, Haruhiko
Suda, Takafumi
CD8‐positive peripheral T cell lymphoma in a patient following long‐term nivolumab for advanced lung adenocarcinoma: A case report
title CD8‐positive peripheral T cell lymphoma in a patient following long‐term nivolumab for advanced lung adenocarcinoma: A case report
title_full CD8‐positive peripheral T cell lymphoma in a patient following long‐term nivolumab for advanced lung adenocarcinoma: A case report
title_fullStr CD8‐positive peripheral T cell lymphoma in a patient following long‐term nivolumab for advanced lung adenocarcinoma: A case report
title_full_unstemmed CD8‐positive peripheral T cell lymphoma in a patient following long‐term nivolumab for advanced lung adenocarcinoma: A case report
title_short CD8‐positive peripheral T cell lymphoma in a patient following long‐term nivolumab for advanced lung adenocarcinoma: A case report
title_sort cd8‐positive peripheral t cell lymphoma in a patient following long‐term nivolumab for advanced lung adenocarcinoma: a case report
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169286/
https://www.ncbi.nlm.nih.gov/pubmed/33939308
http://dx.doi.org/10.1111/1759-7714.13966
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