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Variant-genetic and transcript-expression analysis showed a role for the chemokine-receptor CCR5 in COVID-19 severity

The chemokine receptor CCR5 has been implicated in COVID-19. CCR5 and its ligands are overexpressed in patients. The pharmacological targeting of CCR5 would improve the COVID-19 severity. We sought to investigate the role of the CCR5-Δ32 variant (rs333) in COVID-19. The CCR5-Δ32 was genotyped in 801...

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Detalles Bibliográficos
Autores principales: Cuesta-Llavona, Elías, Gómez, Juan, Albaiceta, Guillermo M., Amado-Rodríguez, Laura, García-Clemente, Marta, Gutiérrez-Rodríguez, José, López-Alonso, Inés, Hermida, Tamara, Enríquez, Ana I., Hernández-González, Cristina, Gil-Peña, Helena, Domínguez-Garrido, Elena, Pérez-Oliveira, Sergio, Alvarez, Victoria, López-Larrea, Carlos, Suarez-Alvarez, Beatriz, Tranche, Salvador, Jimeno-Demuth, Francisco J., Coto, Eliecer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169316/
https://www.ncbi.nlm.nih.gov/pubmed/34116286
http://dx.doi.org/10.1016/j.intimp.2021.107825
Descripción
Sumario:The chemokine receptor CCR5 has been implicated in COVID-19. CCR5 and its ligands are overexpressed in patients. The pharmacological targeting of CCR5 would improve the COVID-19 severity. We sought to investigate the role of the CCR5-Δ32 variant (rs333) in COVID-19. The CCR5-Δ32 was genotyped in 801 patients (353 in the intensive care unit, ICU) and 660 healthy controls, and the deletion was significantly less frequent in hospitalysed COVID-19 than in healthy controls (p = 0.01, OR = 0.66, 95%CI = 0.49–0.88). Of note, we did not find homozygotes among the patients, compared to 1% of the controls. The CCR5 transcript was measured in leukocytes from 85 patients and 40 controls. We found a significantly higher expression of the CCR5 transcript among the patients, with significant difference when comparing the non-deletion carriers (controls = 35; patients = 81; p = 0.01). ICU-patients showed non-significantly higher expression than no-ICU cases. Our study points to CCR5 as a genetic marker for COVID-19. The pharmacological targeting of CCR5 should be a promising treatment for COVID-19.