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Variant-genetic and transcript-expression analysis showed a role for the chemokine-receptor CCR5 in COVID-19 severity

The chemokine receptor CCR5 has been implicated in COVID-19. CCR5 and its ligands are overexpressed in patients. The pharmacological targeting of CCR5 would improve the COVID-19 severity. We sought to investigate the role of the CCR5-Δ32 variant (rs333) in COVID-19. The CCR5-Δ32 was genotyped in 801...

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Autores principales: Cuesta-Llavona, Elías, Gómez, Juan, Albaiceta, Guillermo M., Amado-Rodríguez, Laura, García-Clemente, Marta, Gutiérrez-Rodríguez, José, López-Alonso, Inés, Hermida, Tamara, Enríquez, Ana I., Hernández-González, Cristina, Gil-Peña, Helena, Domínguez-Garrido, Elena, Pérez-Oliveira, Sergio, Alvarez, Victoria, López-Larrea, Carlos, Suarez-Alvarez, Beatriz, Tranche, Salvador, Jimeno-Demuth, Francisco J., Coto, Eliecer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169316/
https://www.ncbi.nlm.nih.gov/pubmed/34116286
http://dx.doi.org/10.1016/j.intimp.2021.107825
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author Cuesta-Llavona, Elías
Gómez, Juan
Albaiceta, Guillermo M.
Amado-Rodríguez, Laura
García-Clemente, Marta
Gutiérrez-Rodríguez, José
López-Alonso, Inés
Hermida, Tamara
Enríquez, Ana I.
Hernández-González, Cristina
Gil-Peña, Helena
Domínguez-Garrido, Elena
Pérez-Oliveira, Sergio
Alvarez, Victoria
López-Larrea, Carlos
Suarez-Alvarez, Beatriz
Tranche, Salvador
Jimeno-Demuth, Francisco J.
Coto, Eliecer
author_facet Cuesta-Llavona, Elías
Gómez, Juan
Albaiceta, Guillermo M.
Amado-Rodríguez, Laura
García-Clemente, Marta
Gutiérrez-Rodríguez, José
López-Alonso, Inés
Hermida, Tamara
Enríquez, Ana I.
Hernández-González, Cristina
Gil-Peña, Helena
Domínguez-Garrido, Elena
Pérez-Oliveira, Sergio
Alvarez, Victoria
López-Larrea, Carlos
Suarez-Alvarez, Beatriz
Tranche, Salvador
Jimeno-Demuth, Francisco J.
Coto, Eliecer
author_sort Cuesta-Llavona, Elías
collection PubMed
description The chemokine receptor CCR5 has been implicated in COVID-19. CCR5 and its ligands are overexpressed in patients. The pharmacological targeting of CCR5 would improve the COVID-19 severity. We sought to investigate the role of the CCR5-Δ32 variant (rs333) in COVID-19. The CCR5-Δ32 was genotyped in 801 patients (353 in the intensive care unit, ICU) and 660 healthy controls, and the deletion was significantly less frequent in hospitalysed COVID-19 than in healthy controls (p = 0.01, OR = 0.66, 95%CI = 0.49–0.88). Of note, we did not find homozygotes among the patients, compared to 1% of the controls. The CCR5 transcript was measured in leukocytes from 85 patients and 40 controls. We found a significantly higher expression of the CCR5 transcript among the patients, with significant difference when comparing the non-deletion carriers (controls = 35; patients = 81; p = 0.01). ICU-patients showed non-significantly higher expression than no-ICU cases. Our study points to CCR5 as a genetic marker for COVID-19. The pharmacological targeting of CCR5 should be a promising treatment for COVID-19.
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spelling pubmed-81693162021-06-02 Variant-genetic and transcript-expression analysis showed a role for the chemokine-receptor CCR5 in COVID-19 severity Cuesta-Llavona, Elías Gómez, Juan Albaiceta, Guillermo M. Amado-Rodríguez, Laura García-Clemente, Marta Gutiérrez-Rodríguez, José López-Alonso, Inés Hermida, Tamara Enríquez, Ana I. Hernández-González, Cristina Gil-Peña, Helena Domínguez-Garrido, Elena Pérez-Oliveira, Sergio Alvarez, Victoria López-Larrea, Carlos Suarez-Alvarez, Beatriz Tranche, Salvador Jimeno-Demuth, Francisco J. Coto, Eliecer Int Immunopharmacol Short Communication The chemokine receptor CCR5 has been implicated in COVID-19. CCR5 and its ligands are overexpressed in patients. The pharmacological targeting of CCR5 would improve the COVID-19 severity. We sought to investigate the role of the CCR5-Δ32 variant (rs333) in COVID-19. The CCR5-Δ32 was genotyped in 801 patients (353 in the intensive care unit, ICU) and 660 healthy controls, and the deletion was significantly less frequent in hospitalysed COVID-19 than in healthy controls (p = 0.01, OR = 0.66, 95%CI = 0.49–0.88). Of note, we did not find homozygotes among the patients, compared to 1% of the controls. The CCR5 transcript was measured in leukocytes from 85 patients and 40 controls. We found a significantly higher expression of the CCR5 transcript among the patients, with significant difference when comparing the non-deletion carriers (controls = 35; patients = 81; p = 0.01). ICU-patients showed non-significantly higher expression than no-ICU cases. Our study points to CCR5 as a genetic marker for COVID-19. The pharmacological targeting of CCR5 should be a promising treatment for COVID-19. Elsevier B.V. 2021-09 2021-06-02 /pmc/articles/PMC8169316/ /pubmed/34116286 http://dx.doi.org/10.1016/j.intimp.2021.107825 Text en © 2021 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Cuesta-Llavona, Elías
Gómez, Juan
Albaiceta, Guillermo M.
Amado-Rodríguez, Laura
García-Clemente, Marta
Gutiérrez-Rodríguez, José
López-Alonso, Inés
Hermida, Tamara
Enríquez, Ana I.
Hernández-González, Cristina
Gil-Peña, Helena
Domínguez-Garrido, Elena
Pérez-Oliveira, Sergio
Alvarez, Victoria
López-Larrea, Carlos
Suarez-Alvarez, Beatriz
Tranche, Salvador
Jimeno-Demuth, Francisco J.
Coto, Eliecer
Variant-genetic and transcript-expression analysis showed a role for the chemokine-receptor CCR5 in COVID-19 severity
title Variant-genetic and transcript-expression analysis showed a role for the chemokine-receptor CCR5 in COVID-19 severity
title_full Variant-genetic and transcript-expression analysis showed a role for the chemokine-receptor CCR5 in COVID-19 severity
title_fullStr Variant-genetic and transcript-expression analysis showed a role for the chemokine-receptor CCR5 in COVID-19 severity
title_full_unstemmed Variant-genetic and transcript-expression analysis showed a role for the chemokine-receptor CCR5 in COVID-19 severity
title_short Variant-genetic and transcript-expression analysis showed a role for the chemokine-receptor CCR5 in COVID-19 severity
title_sort variant-genetic and transcript-expression analysis showed a role for the chemokine-receptor ccr5 in covid-19 severity
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169316/
https://www.ncbi.nlm.nih.gov/pubmed/34116286
http://dx.doi.org/10.1016/j.intimp.2021.107825
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