Oxford–AstraZeneca COVID-19 vaccine: need of a reasoned and effective vaccine campaign

OBJECTIVES: A strong COVID-19 vaccine campaign is needed to reach the herd immunity and reduce this pandemic infection. STUDY DESIGN: In the Foch Hospital, France, in February 2021, 451 healthcare workers were vaccinated by a first dose of AstraZeneca vaccine. METHODS: Adverse effects were reported...

Descripción completa

Detalles Bibliográficos
Autores principales: Vallée, A., Chan-Hew-Wai, A., Bonan, B., Lesprit, P., Parquin, F., Catherinot, É., Choucair, J., Billard, D., Amiel-Taieb, C., Camps, È., Cerf, C., Zucman, D., Fourn, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society for Public Health. Published by Elsevier Ltd. 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169320/
https://www.ncbi.nlm.nih.gov/pubmed/34198072
http://dx.doi.org/10.1016/j.puhe.2021.05.030
_version_ 1783702034651807744
author Vallée, A.
Chan-Hew-Wai, A.
Bonan, B.
Lesprit, P.
Parquin, F.
Catherinot, É.
Choucair, J.
Billard, D.
Amiel-Taieb, C.
Camps, È.
Cerf, C.
Zucman, D.
Fourn, E.
author_facet Vallée, A.
Chan-Hew-Wai, A.
Bonan, B.
Lesprit, P.
Parquin, F.
Catherinot, É.
Choucair, J.
Billard, D.
Amiel-Taieb, C.
Camps, È.
Cerf, C.
Zucman, D.
Fourn, E.
author_sort Vallée, A.
collection PubMed
description OBJECTIVES: A strong COVID-19 vaccine campaign is needed to reach the herd immunity and reduce this pandemic infection. STUDY DESIGN: In the Foch Hospital, France, in February 2021, 451 healthcare workers were vaccinated by a first dose of AstraZeneca vaccine. METHODS: Adverse effects were reported to our pharmaco-vigilance circuit, by an online and anonymous questionnaire following the first weeks of the vaccinal campaign to healthcare workers. RESULTS: Two hundred seventy-four (60.8%) of them reported multiple adverse effects. Main adverse effects reported were feverish state/chills (65.7%), fatigue/physical discomfort (62.4%), arthralgia/muscle pain (61.0%) and fever (44.5%). CONCLUSIONS: On March 2021 many European countries suspended AstraZeneca vaccine for one week due to safety uncertainty. Thus, confidence in its efficacy is undermined. However, the benefit/risk balance is clearly in favor of vaccination.
format Online
Article
Text
id pubmed-8169320
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher The Royal Society for Public Health. Published by Elsevier Ltd.
record_format MEDLINE/PubMed
spelling pubmed-81693202021-06-02 Oxford–AstraZeneca COVID-19 vaccine: need of a reasoned and effective vaccine campaign Vallée, A. Chan-Hew-Wai, A. Bonan, B. Lesprit, P. Parquin, F. Catherinot, É. Choucair, J. Billard, D. Amiel-Taieb, C. Camps, È. Cerf, C. Zucman, D. Fourn, E. Public Health Short Communication OBJECTIVES: A strong COVID-19 vaccine campaign is needed to reach the herd immunity and reduce this pandemic infection. STUDY DESIGN: In the Foch Hospital, France, in February 2021, 451 healthcare workers were vaccinated by a first dose of AstraZeneca vaccine. METHODS: Adverse effects were reported to our pharmaco-vigilance circuit, by an online and anonymous questionnaire following the first weeks of the vaccinal campaign to healthcare workers. RESULTS: Two hundred seventy-four (60.8%) of them reported multiple adverse effects. Main adverse effects reported were feverish state/chills (65.7%), fatigue/physical discomfort (62.4%), arthralgia/muscle pain (61.0%) and fever (44.5%). CONCLUSIONS: On March 2021 many European countries suspended AstraZeneca vaccine for one week due to safety uncertainty. Thus, confidence in its efficacy is undermined. However, the benefit/risk balance is clearly in favor of vaccination. The Royal Society for Public Health. Published by Elsevier Ltd. 2021-07 2021-06-02 /pmc/articles/PMC8169320/ /pubmed/34198072 http://dx.doi.org/10.1016/j.puhe.2021.05.030 Text en © 2021 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Vallée, A.
Chan-Hew-Wai, A.
Bonan, B.
Lesprit, P.
Parquin, F.
Catherinot, É.
Choucair, J.
Billard, D.
Amiel-Taieb, C.
Camps, È.
Cerf, C.
Zucman, D.
Fourn, E.
Oxford–AstraZeneca COVID-19 vaccine: need of a reasoned and effective vaccine campaign
title Oxford–AstraZeneca COVID-19 vaccine: need of a reasoned and effective vaccine campaign
title_full Oxford–AstraZeneca COVID-19 vaccine: need of a reasoned and effective vaccine campaign
title_fullStr Oxford–AstraZeneca COVID-19 vaccine: need of a reasoned and effective vaccine campaign
title_full_unstemmed Oxford–AstraZeneca COVID-19 vaccine: need of a reasoned and effective vaccine campaign
title_short Oxford–AstraZeneca COVID-19 vaccine: need of a reasoned and effective vaccine campaign
title_sort oxford–astrazeneca covid-19 vaccine: need of a reasoned and effective vaccine campaign
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169320/
https://www.ncbi.nlm.nih.gov/pubmed/34198072
http://dx.doi.org/10.1016/j.puhe.2021.05.030
work_keys_str_mv AT valleea oxfordastrazenecacovid19vaccineneedofareasonedandeffectivevaccinecampaign
AT chanhewwaia oxfordastrazenecacovid19vaccineneedofareasonedandeffectivevaccinecampaign
AT bonanb oxfordastrazenecacovid19vaccineneedofareasonedandeffectivevaccinecampaign
AT lespritp oxfordastrazenecacovid19vaccineneedofareasonedandeffectivevaccinecampaign
AT parquinf oxfordastrazenecacovid19vaccineneedofareasonedandeffectivevaccinecampaign
AT catherinote oxfordastrazenecacovid19vaccineneedofareasonedandeffectivevaccinecampaign
AT choucairj oxfordastrazenecacovid19vaccineneedofareasonedandeffectivevaccinecampaign
AT billardd oxfordastrazenecacovid19vaccineneedofareasonedandeffectivevaccinecampaign
AT amieltaiebc oxfordastrazenecacovid19vaccineneedofareasonedandeffectivevaccinecampaign
AT campse oxfordastrazenecacovid19vaccineneedofareasonedandeffectivevaccinecampaign
AT cerfc oxfordastrazenecacovid19vaccineneedofareasonedandeffectivevaccinecampaign
AT zucmand oxfordastrazenecacovid19vaccineneedofareasonedandeffectivevaccinecampaign
AT fourne oxfordastrazenecacovid19vaccineneedofareasonedandeffectivevaccinecampaign

Ejemplares similares