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Association of crossing capillaries in the finger nailfold with diabetic retinopathy in type 2 diabetes mellitus

AIMS/INTRODUCTION: Crossing capillaries in the finger nailfold might potentially be a novel diabetic retinopathy (DR) biomarker that could be assessed non‐invasively in the clinical setting. However, the association between crossing capillaries and DR is controversial. This study aimed to investigat...

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Autores principales: Shikama, Maiko, Sonoda, Nao, Morimoto, Akiko, Suga, Sayaka, Tajima, Tetsuya, Kozawa, Junji, Maeda, Norikazu, Otsuki, Michio, Matsuoka, Taka‐Aki, Shimomura, Iichiro, Ohno, Yuko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169354/
https://www.ncbi.nlm.nih.gov/pubmed/33070436
http://dx.doi.org/10.1111/jdi.13444
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author Shikama, Maiko
Sonoda, Nao
Morimoto, Akiko
Suga, Sayaka
Tajima, Tetsuya
Kozawa, Junji
Maeda, Norikazu
Otsuki, Michio
Matsuoka, Taka‐Aki
Shimomura, Iichiro
Ohno, Yuko
author_facet Shikama, Maiko
Sonoda, Nao
Morimoto, Akiko
Suga, Sayaka
Tajima, Tetsuya
Kozawa, Junji
Maeda, Norikazu
Otsuki, Michio
Matsuoka, Taka‐Aki
Shimomura, Iichiro
Ohno, Yuko
author_sort Shikama, Maiko
collection PubMed
description AIMS/INTRODUCTION: Crossing capillaries in the finger nailfold might potentially be a novel diabetic retinopathy (DR) biomarker that could be assessed non‐invasively in the clinical setting. However, the association between crossing capillaries and DR is controversial. This study aimed to investigate the association between the percentage of crossing capillaries in the finger nailfold and DR in patients with type 2 diabetes mellitus. MATERIALS AND METHODS: This cross‐sectional study enrolled 108 type 2 diabetes mellitus patients (aged 40–75 years) who visited the outpatient diabetic clinic at Osaka University Hospital, Osaka, Japan, between May and October 2019. Capillary morphology was assessed using nailfold capillaroscopy based on the simple capillaroscopic definitions of the European League Against Rheumatism Study Group. Details of DR and other laboratory data were obtained from medical records. The association between the tertile of the percentage of the crossing capillary and DR was analyzed using multivariable logistic regression. RESULTS: After adjusting for age, sex, diabetes duration, glycated hemoglobin, systolic blood pressure, body mass index, and use of renin–angiotensin system inhibitor and antihyperlipidemic medication, the percentage of crossing capillaries was significantly associated with DR (multivariable‐adjusted odds ratios for increasing tertiles of the percentage of crossing capillary: 1 [reference], 2.05 [95% confidence interval 0.53–7.94], and 4.33 [95% confidence interval 1.16–16.21]; P‐trend = 0.028). CONCLUSIONS: A higher percentage of crossing capillaries in the nailfold was associated with a higher risk of DR, independent of traditional risk and inhibiting factors, in patients with type 2 diabetes mellitus.
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spelling pubmed-81693542021-06-05 Association of crossing capillaries in the finger nailfold with diabetic retinopathy in type 2 diabetes mellitus Shikama, Maiko Sonoda, Nao Morimoto, Akiko Suga, Sayaka Tajima, Tetsuya Kozawa, Junji Maeda, Norikazu Otsuki, Michio Matsuoka, Taka‐Aki Shimomura, Iichiro Ohno, Yuko J Diabetes Investig Articles AIMS/INTRODUCTION: Crossing capillaries in the finger nailfold might potentially be a novel diabetic retinopathy (DR) biomarker that could be assessed non‐invasively in the clinical setting. However, the association between crossing capillaries and DR is controversial. This study aimed to investigate the association between the percentage of crossing capillaries in the finger nailfold and DR in patients with type 2 diabetes mellitus. MATERIALS AND METHODS: This cross‐sectional study enrolled 108 type 2 diabetes mellitus patients (aged 40–75 years) who visited the outpatient diabetic clinic at Osaka University Hospital, Osaka, Japan, between May and October 2019. Capillary morphology was assessed using nailfold capillaroscopy based on the simple capillaroscopic definitions of the European League Against Rheumatism Study Group. Details of DR and other laboratory data were obtained from medical records. The association between the tertile of the percentage of the crossing capillary and DR was analyzed using multivariable logistic regression. RESULTS: After adjusting for age, sex, diabetes duration, glycated hemoglobin, systolic blood pressure, body mass index, and use of renin–angiotensin system inhibitor and antihyperlipidemic medication, the percentage of crossing capillaries was significantly associated with DR (multivariable‐adjusted odds ratios for increasing tertiles of the percentage of crossing capillary: 1 [reference], 2.05 [95% confidence interval 0.53–7.94], and 4.33 [95% confidence interval 1.16–16.21]; P‐trend = 0.028). CONCLUSIONS: A higher percentage of crossing capillaries in the nailfold was associated with a higher risk of DR, independent of traditional risk and inhibiting factors, in patients with type 2 diabetes mellitus. John Wiley and Sons Inc. 2020-11-10 2021-06 /pmc/articles/PMC8169354/ /pubmed/33070436 http://dx.doi.org/10.1111/jdi.13444 Text en © 2020 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Articles
Shikama, Maiko
Sonoda, Nao
Morimoto, Akiko
Suga, Sayaka
Tajima, Tetsuya
Kozawa, Junji
Maeda, Norikazu
Otsuki, Michio
Matsuoka, Taka‐Aki
Shimomura, Iichiro
Ohno, Yuko
Association of crossing capillaries in the finger nailfold with diabetic retinopathy in type 2 diabetes mellitus
title Association of crossing capillaries in the finger nailfold with diabetic retinopathy in type 2 diabetes mellitus
title_full Association of crossing capillaries in the finger nailfold with diabetic retinopathy in type 2 diabetes mellitus
title_fullStr Association of crossing capillaries in the finger nailfold with diabetic retinopathy in type 2 diabetes mellitus
title_full_unstemmed Association of crossing capillaries in the finger nailfold with diabetic retinopathy in type 2 diabetes mellitus
title_short Association of crossing capillaries in the finger nailfold with diabetic retinopathy in type 2 diabetes mellitus
title_sort association of crossing capillaries in the finger nailfold with diabetic retinopathy in type 2 diabetes mellitus
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169354/
https://www.ncbi.nlm.nih.gov/pubmed/33070436
http://dx.doi.org/10.1111/jdi.13444
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