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Exposure to metals and morbidity at eight years follow-up in women of childbearing age
This exploratory study was aimed to investigate the link between toxic metal content in women’s urine and their morbidity 2 years before and 6 years after the test. Concentrations of 25 metals in urine were analyzed for 111 pregnant women collected prior to delivery. All women were of Arab-Bedouin o...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169725/ https://www.ncbi.nlm.nih.gov/pubmed/34075123 http://dx.doi.org/10.1038/s41598-021-90904-1 |
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author | Karakis, Isabella Baumfeld, Yael Landau, Daniella Gat, Roni Shemesh, Nofar Yitshak-Sade, Maayan Tirosh, Ofir Sarov, Batia Novack, Lena |
author_facet | Karakis, Isabella Baumfeld, Yael Landau, Daniella Gat, Roni Shemesh, Nofar Yitshak-Sade, Maayan Tirosh, Ofir Sarov, Batia Novack, Lena |
author_sort | Karakis, Isabella |
collection | PubMed |
description | This exploratory study was aimed to investigate the link between toxic metal content in women’s urine and their morbidity 2 years before and 6 years after the test. Concentrations of 25 metals in urine were analyzed for 111 pregnant women collected prior to delivery. All women were of Arab-Bedouin origin. Information on primary care and hospital visits during the study period was obtained. In a Poisson regression model, a health outcome was regressed over metal exposure and other factors. A Weighted Quantile Sum Regression (WQS) approach was used to indicate metals dominating in their possible impact on women's morbidity. Obesity was the most frequently diagnosed condition in this population (27.9%). Diagnoses in a neurological category accounted for 36.0%, asthma or respiratory—25.2%, psychiatric—12.6%, cardiovascular—14.4% and cancer or benign growth—for 13.5%. Based on WQS analysis, cancer and benign growth were mostly attributed to the increased levels of cadmium, cardiovascular outcomes were linked with lead, and obesity was found associated with elevated levels of nickel. Hematological, neurological and respiratory outcomes were attributed to multiple non-essential metals. The health and exposure profile of women in the study warrants a periodic biomonitoring in attempt to identify and reduce exposure to potentially dangerous elements. |
format | Online Article Text |
id | pubmed-8169725 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-81697252021-06-02 Exposure to metals and morbidity at eight years follow-up in women of childbearing age Karakis, Isabella Baumfeld, Yael Landau, Daniella Gat, Roni Shemesh, Nofar Yitshak-Sade, Maayan Tirosh, Ofir Sarov, Batia Novack, Lena Sci Rep Article This exploratory study was aimed to investigate the link between toxic metal content in women’s urine and their morbidity 2 years before and 6 years after the test. Concentrations of 25 metals in urine were analyzed for 111 pregnant women collected prior to delivery. All women were of Arab-Bedouin origin. Information on primary care and hospital visits during the study period was obtained. In a Poisson regression model, a health outcome was regressed over metal exposure and other factors. A Weighted Quantile Sum Regression (WQS) approach was used to indicate metals dominating in their possible impact on women's morbidity. Obesity was the most frequently diagnosed condition in this population (27.9%). Diagnoses in a neurological category accounted for 36.0%, asthma or respiratory—25.2%, psychiatric—12.6%, cardiovascular—14.4% and cancer or benign growth—for 13.5%. Based on WQS analysis, cancer and benign growth were mostly attributed to the increased levels of cadmium, cardiovascular outcomes were linked with lead, and obesity was found associated with elevated levels of nickel. Hematological, neurological and respiratory outcomes were attributed to multiple non-essential metals. The health and exposure profile of women in the study warrants a periodic biomonitoring in attempt to identify and reduce exposure to potentially dangerous elements. Nature Publishing Group UK 2021-06-01 /pmc/articles/PMC8169725/ /pubmed/34075123 http://dx.doi.org/10.1038/s41598-021-90904-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Karakis, Isabella Baumfeld, Yael Landau, Daniella Gat, Roni Shemesh, Nofar Yitshak-Sade, Maayan Tirosh, Ofir Sarov, Batia Novack, Lena Exposure to metals and morbidity at eight years follow-up in women of childbearing age |
title | Exposure to metals and morbidity at eight years follow-up in women of childbearing age |
title_full | Exposure to metals and morbidity at eight years follow-up in women of childbearing age |
title_fullStr | Exposure to metals and morbidity at eight years follow-up in women of childbearing age |
title_full_unstemmed | Exposure to metals and morbidity at eight years follow-up in women of childbearing age |
title_short | Exposure to metals and morbidity at eight years follow-up in women of childbearing age |
title_sort | exposure to metals and morbidity at eight years follow-up in women of childbearing age |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169725/ https://www.ncbi.nlm.nih.gov/pubmed/34075123 http://dx.doi.org/10.1038/s41598-021-90904-1 |
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