The USP7-TRIM27 axis mediates non-canonical PRC1.1 function and is a druggable target in leukemia

In an attempt to unravel functionality of the non-canonical PRC1.1 Polycomb complex in human leukemogenesis, we show that USP7 and TRIM27 are integral components of PRC1.1. USP7 interactome analyses show that PRC1.1 is the predominant Polycomb complex co-precipitating with USP7. USP7 inhibition resu...

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Detalles Bibliográficos
Autores principales: Maat, Henny, Atsma, Tjerk Jan, Hogeling, Shanna M., Rodríguez López, Aida, Jaques, Jennifer, Olthuis, Mirjam, de Vries, Marcel P., Gravesteijn, Chantal, Brouwers-Vos, Annet Z., van der Meer, Nisha, Datema, Suzan, Salzbrunn, Jonas, Huls, Gerwin, Baas, Roy, Martens, Joost H.A., van den Boom, Vincent, Schuringa, Jan Jacob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169803/
https://www.ncbi.nlm.nih.gov/pubmed/34113809
http://dx.doi.org/10.1016/j.isci.2021.102435

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169803/
https://www.ncbi.nlm.nih.gov/pubmed/34113809
http://dx.doi.org/10.1016/j.isci.2021.102435

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