DHODH inhibition modulates glucose metabolism and circulating GDF15, and improves metabolic balance

Dihydroorotate dehydrogenase (DHODH) is essential for the de novo synthesis of pyrimidine ribonucleotides, and as such, its inhibitors have been long used to treat autoimmune diseases and are in clinical trials for cancer and viral infections. Interestingly, DHODH is located in the inner mitochondri...

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Detalles Bibliográficos
Autores principales: Zhang, Juan, Terán, Graciela, Popa, Mihaela, Madapura, Harsha, Ladds, Marcus James Graeme Watson, Lianoudaki, Danai, Grünler, Jacob, Arsenian-Henriksson, Marie, McCormack, Emmet, Rottenberg, Martin Enrique, Catrina, Sergiu-Bogdan, Laín, Sonia, Darekar, Suhas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169992/
https://www.ncbi.nlm.nih.gov/pubmed/34113829
http://dx.doi.org/10.1016/j.isci.2021.102494

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