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Non-Persistence With Antiplatelet Medications Among Older Patients With Peripheral Arterial Disease
Introduction: Antiplatelet therapy needs to be administered life-long in patients with peripheral arterial disease (PAD). Our study was aimed at 1) the analysis of non-persistence with antiplatelet medication in older PAD patients and 2) identification of patient- and medication-related characterist...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170080/ https://www.ncbi.nlm.nih.gov/pubmed/34093210 http://dx.doi.org/10.3389/fphar.2021.687549 |
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author | Wawruch, Martin Murin, Jan Tesar, Tomas Paduchova, Martina Petrova, Miriam Celovska, Denisa Havelkova, Beata Trnka, Michal Aarnio, Emma |
author_facet | Wawruch, Martin Murin, Jan Tesar, Tomas Paduchova, Martina Petrova, Miriam Celovska, Denisa Havelkova, Beata Trnka, Michal Aarnio, Emma |
author_sort | Wawruch, Martin |
collection | PubMed |
description | Introduction: Antiplatelet therapy needs to be administered life-long in patients with peripheral arterial disease (PAD). Our study was aimed at 1) the analysis of non-persistence with antiplatelet medication in older PAD patients and 2) identification of patient- and medication-related characteristics associated with non-persistence. Methods: The study data was retrieved from the database of the General Health Insurance Company. The study cohort of 9,178 patients aged ≥ 65 years and treated with antiplatelet medications was selected from 21,433 patients in whom PAD was newly diagnosed between 01/2012 and 12/2012. Patients with a 6 months treatment gap without antiplatelet medication prescription were classified as non-persistent. Characteristics associated with non-persistence were identified using the Cox regression. Results: At the end of the 5 years follow-up, 3,032 (33.0%) patients were non-persistent. Age, history of ischemic stroke or myocardial infarction, clopidogrel or combination of aspirin with clopidogrel used at the index date, higher co-payment, general practitioner as index prescriber and higher overall number of medications were associated with persistence, whereas female sex, atrial fibrillation, anxiety disorders, bronchial asthma/chronic obstructive pulmonary disease, being a new antiplatelet medication user (therapy initiated in association with PAD diagnosis), and use of anticoagulants or antiarrhythmic agents were associated with non-persistence. Conclusion: In patients with an increased probability of non-persistence, an increased attention should be paid to improvement of persistence. |
format | Online Article Text |
id | pubmed-8170080 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81700802021-06-03 Non-Persistence With Antiplatelet Medications Among Older Patients With Peripheral Arterial Disease Wawruch, Martin Murin, Jan Tesar, Tomas Paduchova, Martina Petrova, Miriam Celovska, Denisa Havelkova, Beata Trnka, Michal Aarnio, Emma Front Pharmacol Pharmacology Introduction: Antiplatelet therapy needs to be administered life-long in patients with peripheral arterial disease (PAD). Our study was aimed at 1) the analysis of non-persistence with antiplatelet medication in older PAD patients and 2) identification of patient- and medication-related characteristics associated with non-persistence. Methods: The study data was retrieved from the database of the General Health Insurance Company. The study cohort of 9,178 patients aged ≥ 65 years and treated with antiplatelet medications was selected from 21,433 patients in whom PAD was newly diagnosed between 01/2012 and 12/2012. Patients with a 6 months treatment gap without antiplatelet medication prescription were classified as non-persistent. Characteristics associated with non-persistence were identified using the Cox regression. Results: At the end of the 5 years follow-up, 3,032 (33.0%) patients were non-persistent. Age, history of ischemic stroke or myocardial infarction, clopidogrel or combination of aspirin with clopidogrel used at the index date, higher co-payment, general practitioner as index prescriber and higher overall number of medications were associated with persistence, whereas female sex, atrial fibrillation, anxiety disorders, bronchial asthma/chronic obstructive pulmonary disease, being a new antiplatelet medication user (therapy initiated in association with PAD diagnosis), and use of anticoagulants or antiarrhythmic agents were associated with non-persistence. Conclusion: In patients with an increased probability of non-persistence, an increased attention should be paid to improvement of persistence. Frontiers Media S.A. 2021-05-19 /pmc/articles/PMC8170080/ /pubmed/34093210 http://dx.doi.org/10.3389/fphar.2021.687549 Text en Copyright © 2021 Wawruch, Murin, Tesar, Paduchova, Petrova, Celovska, Havelkova, Trnka and Aarnio. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Wawruch, Martin Murin, Jan Tesar, Tomas Paduchova, Martina Petrova, Miriam Celovska, Denisa Havelkova, Beata Trnka, Michal Aarnio, Emma Non-Persistence With Antiplatelet Medications Among Older Patients With Peripheral Arterial Disease |
title | Non-Persistence With Antiplatelet Medications Among Older Patients With Peripheral Arterial Disease |
title_full | Non-Persistence With Antiplatelet Medications Among Older Patients With Peripheral Arterial Disease |
title_fullStr | Non-Persistence With Antiplatelet Medications Among Older Patients With Peripheral Arterial Disease |
title_full_unstemmed | Non-Persistence With Antiplatelet Medications Among Older Patients With Peripheral Arterial Disease |
title_short | Non-Persistence With Antiplatelet Medications Among Older Patients With Peripheral Arterial Disease |
title_sort | non-persistence with antiplatelet medications among older patients with peripheral arterial disease |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170080/ https://www.ncbi.nlm.nih.gov/pubmed/34093210 http://dx.doi.org/10.3389/fphar.2021.687549 |
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