Impaired Vitamin D Signaling in T Cells From a Family With Hereditary Vitamin D Resistant Rickets

The active form of vitamin D, 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), mediates its immunomodulatory effects by binding to the vitamin D receptor (VDR). Here, we describe a new point mutation in the DNA-binding domain of the VDR and its consequences for 1,25(OH)(2)D(3) signaling in T cells from...

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Detalles Bibliográficos
Autores principales: Al-Jaberi, Fatima A. H., Kongsbak-Wismann, Martin, Aguayo-Orozco, Alejandro, Krogh, Nicolai, Buus, Terkild B., Lopez, Daniel V., Rode, Anna K. O., Gravesen, Eva, Olgaard, Klaus, Brunak, Søren, Woetmann, Anders, Ødum, Niels, Bonefeld, Charlotte M., Geisler, Carsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170129/
https://www.ncbi.nlm.nih.gov/pubmed/34093587
http://dx.doi.org/10.3389/fimmu.2021.684015

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