DNA Methylation, Deamination, and Translesion Synthesis Combine to Generate Footprint Mutations in Cancer Driver Genes in B-Cell Derived Lymphomas and Other Cancers

Cancer genomes harbor numerous genomic alterations and many cancers accumulate thousands of nucleotide sequence variations. A prominent fraction of these mutations arises as a consequence of the off-target activity of DNA/RNA editing cytosine deaminases followed by the replication/repair of edited s...

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Detalles Bibliográficos
Autores principales: Rogozin, Igor B., Roche-Lima, Abiel, Tyryshkin, Kathrin, Carrasquillo-Carrión, Kelvin, Lada, Artem G., Poliakov, Lennard Y., Schwartz, Elena, Saura, Andreu, Yurchenko, Vyacheslav, Cooper, David N., Panchenko, Anna R., Pavlov, Youri I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170131/
https://www.ncbi.nlm.nih.gov/pubmed/34093666
http://dx.doi.org/10.3389/fgene.2021.671866

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