Cargando…
Bilateral massive nephromegaly–A rare presentation of t-cell acute lymphoblastic leukemia
INTRODUCTION: Renal infiltration by leukemia causing massive bilateral nephromegaly is an extremely rare presentation of T-cell acute lymphoblastic leukemia(T-ALL). CASE REPORT: 18-month-old female toddler presented with fever and progressive abdominal distension of 4–6 weeks duration. Imaging revea...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170146/ https://www.ncbi.nlm.nih.gov/pubmed/34113542 http://dx.doi.org/10.1016/j.lrr.2021.100246 |
_version_ | 1783702176602783744 |
---|---|
author | Vijayasekharan, Kalasekhar Bhat K, Vasudeva Venkatagiri, Archana M Godkhindi, Vishwapriya M Laxminarayana, Sindhura Lakshmi Koulmane Belurkar, Sushma |
author_facet | Vijayasekharan, Kalasekhar Bhat K, Vasudeva Venkatagiri, Archana M Godkhindi, Vishwapriya M Laxminarayana, Sindhura Lakshmi Koulmane Belurkar, Sushma |
author_sort | Vijayasekharan, Kalasekhar |
collection | PubMed |
description | INTRODUCTION: Renal infiltration by leukemia causing massive bilateral nephromegaly is an extremely rare presentation of T-cell acute lymphoblastic leukemia(T-ALL). CASE REPORT: 18-month-old female toddler presented with fever and progressive abdominal distension of 4–6 weeks duration. Imaging revealed bilateral massively enlarged kidneys with normal excretion. Peripheral blood counts and smear examination was unremarkable and immunophenotypic evaluation of marrow was consistent with T-ALL. Chest imaging was unremarkable. She was started on modified Indian Childhood Collaborative Leukemia Group (ICiCLe) ALL protocol. Even with the best anti-tumor lysis syndrome (TLS) prophylaxis the child required two sessions of hemodialysis. An end-induction morphological remission & end-consolidation negative minimal residual disease (MRD) could be achieved. CONCLUSION: Bilateral massive nephromegaly is an extremely rare presentation of T-ALL. This case emphasizes the unusual presentation, need for prompt remediation of TLS, and most importantly the use of early intensification with four drug anthracycline & dexamethasone-based therapy for the treatment of T-ALL in children. |
format | Online Article Text |
id | pubmed-8170146 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-81701462021-06-09 Bilateral massive nephromegaly–A rare presentation of t-cell acute lymphoblastic leukemia Vijayasekharan, Kalasekhar Bhat K, Vasudeva Venkatagiri, Archana M Godkhindi, Vishwapriya M Laxminarayana, Sindhura Lakshmi Koulmane Belurkar, Sushma Leuk Res Rep Article INTRODUCTION: Renal infiltration by leukemia causing massive bilateral nephromegaly is an extremely rare presentation of T-cell acute lymphoblastic leukemia(T-ALL). CASE REPORT: 18-month-old female toddler presented with fever and progressive abdominal distension of 4–6 weeks duration. Imaging revealed bilateral massively enlarged kidneys with normal excretion. Peripheral blood counts and smear examination was unremarkable and immunophenotypic evaluation of marrow was consistent with T-ALL. Chest imaging was unremarkable. She was started on modified Indian Childhood Collaborative Leukemia Group (ICiCLe) ALL protocol. Even with the best anti-tumor lysis syndrome (TLS) prophylaxis the child required two sessions of hemodialysis. An end-induction morphological remission & end-consolidation negative minimal residual disease (MRD) could be achieved. CONCLUSION: Bilateral massive nephromegaly is an extremely rare presentation of T-ALL. This case emphasizes the unusual presentation, need for prompt remediation of TLS, and most importantly the use of early intensification with four drug anthracycline & dexamethasone-based therapy for the treatment of T-ALL in children. Elsevier 2021-05-19 /pmc/articles/PMC8170146/ /pubmed/34113542 http://dx.doi.org/10.1016/j.lrr.2021.100246 Text en © 2021 The Authors. Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Vijayasekharan, Kalasekhar Bhat K, Vasudeva Venkatagiri, Archana M Godkhindi, Vishwapriya M Laxminarayana, Sindhura Lakshmi Koulmane Belurkar, Sushma Bilateral massive nephromegaly–A rare presentation of t-cell acute lymphoblastic leukemia |
title | Bilateral massive nephromegaly–A rare presentation of t-cell acute lymphoblastic leukemia |
title_full | Bilateral massive nephromegaly–A rare presentation of t-cell acute lymphoblastic leukemia |
title_fullStr | Bilateral massive nephromegaly–A rare presentation of t-cell acute lymphoblastic leukemia |
title_full_unstemmed | Bilateral massive nephromegaly–A rare presentation of t-cell acute lymphoblastic leukemia |
title_short | Bilateral massive nephromegaly–A rare presentation of t-cell acute lymphoblastic leukemia |
title_sort | bilateral massive nephromegaly–a rare presentation of t-cell acute lymphoblastic leukemia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170146/ https://www.ncbi.nlm.nih.gov/pubmed/34113542 http://dx.doi.org/10.1016/j.lrr.2021.100246 |
work_keys_str_mv | AT vijayasekharankalasekhar bilateralmassivenephromegalyararepresentationoftcellacutelymphoblasticleukemia AT bhatkvasudeva bilateralmassivenephromegalyararepresentationoftcellacutelymphoblasticleukemia AT venkatagiriarchanam bilateralmassivenephromegalyararepresentationoftcellacutelymphoblasticleukemia AT godkhindivishwapriyam bilateralmassivenephromegalyararepresentationoftcellacutelymphoblasticleukemia AT laxminarayanasindhuralakshmikoulmane bilateralmassivenephromegalyararepresentationoftcellacutelymphoblasticleukemia AT belurkarsushma bilateralmassivenephromegalyararepresentationoftcellacutelymphoblasticleukemia |