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Anti-lipopolysaccharide antibody mitigates ruminal lipopolysaccharide release without acute-phase inflammation or liver transcriptomic responses in Holstein bulls

Anti-lipopolysaccharide (LPS) antibody administration has the potential benefits of neutralizing and consequently controlling rumen-derived LPS during subacute ruminal acidosis. Four Holstein bulls were used in this crossover study with a 2-week wash-out period. Anti-LPS antibody (0 or 4 g) was admi...

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Autores principales: Mizuguchi, Hitoshi, Kizaki, Keiichiro, Kimura, Atsushi, Kushibiki, Shiro, Ikuta, Kentaro, Kim, Yo-Han, Sato, Shigeru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Veterinary Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170223/
https://www.ncbi.nlm.nih.gov/pubmed/34056875
http://dx.doi.org/10.4142/jvs.2021.22.e34
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author Mizuguchi, Hitoshi
Kizaki, Keiichiro
Kimura, Atsushi
Kushibiki, Shiro
Ikuta, Kentaro
Kim, Yo-Han
Sato, Shigeru
author_facet Mizuguchi, Hitoshi
Kizaki, Keiichiro
Kimura, Atsushi
Kushibiki, Shiro
Ikuta, Kentaro
Kim, Yo-Han
Sato, Shigeru
author_sort Mizuguchi, Hitoshi
collection PubMed
description Anti-lipopolysaccharide (LPS) antibody administration has the potential benefits of neutralizing and consequently controlling rumen-derived LPS during subacute ruminal acidosis. Four Holstein bulls were used in this crossover study with a 2-week wash-out period. Anti-LPS antibody (0 or 4 g) was administered once daily for 14 days. Significantly lower ruminal LPS and higher 1-h mean ruminal pH were identified in the 4 g group. However, blood metabolites, acute-phase proteins, cytokines, and hepatic transcriptomes were not different between the two groups. Therefore, anti-LPS antibody administration mitigated ruminal LPS release and pH depression without accompanying responses in acute-phase inflammation or hepatic transcriptomic expression.
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spelling pubmed-81702232021-06-04 Anti-lipopolysaccharide antibody mitigates ruminal lipopolysaccharide release without acute-phase inflammation or liver transcriptomic responses in Holstein bulls Mizuguchi, Hitoshi Kizaki, Keiichiro Kimura, Atsushi Kushibiki, Shiro Ikuta, Kentaro Kim, Yo-Han Sato, Shigeru J Vet Sci Rapid Communication Anti-lipopolysaccharide (LPS) antibody administration has the potential benefits of neutralizing and consequently controlling rumen-derived LPS during subacute ruminal acidosis. Four Holstein bulls were used in this crossover study with a 2-week wash-out period. Anti-LPS antibody (0 or 4 g) was administered once daily for 14 days. Significantly lower ruminal LPS and higher 1-h mean ruminal pH were identified in the 4 g group. However, blood metabolites, acute-phase proteins, cytokines, and hepatic transcriptomes were not different between the two groups. Therefore, anti-LPS antibody administration mitigated ruminal LPS release and pH depression without accompanying responses in acute-phase inflammation or hepatic transcriptomic expression. The Korean Society of Veterinary Science 2021-05 2021-04-19 /pmc/articles/PMC8170223/ /pubmed/34056875 http://dx.doi.org/10.4142/jvs.2021.22.e34 Text en © 2021 The Korean Society of Veterinary Science https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Rapid Communication
Mizuguchi, Hitoshi
Kizaki, Keiichiro
Kimura, Atsushi
Kushibiki, Shiro
Ikuta, Kentaro
Kim, Yo-Han
Sato, Shigeru
Anti-lipopolysaccharide antibody mitigates ruminal lipopolysaccharide release without acute-phase inflammation or liver transcriptomic responses in Holstein bulls
title Anti-lipopolysaccharide antibody mitigates ruminal lipopolysaccharide release without acute-phase inflammation or liver transcriptomic responses in Holstein bulls
title_full Anti-lipopolysaccharide antibody mitigates ruminal lipopolysaccharide release without acute-phase inflammation or liver transcriptomic responses in Holstein bulls
title_fullStr Anti-lipopolysaccharide antibody mitigates ruminal lipopolysaccharide release without acute-phase inflammation or liver transcriptomic responses in Holstein bulls
title_full_unstemmed Anti-lipopolysaccharide antibody mitigates ruminal lipopolysaccharide release without acute-phase inflammation or liver transcriptomic responses in Holstein bulls
title_short Anti-lipopolysaccharide antibody mitigates ruminal lipopolysaccharide release without acute-phase inflammation or liver transcriptomic responses in Holstein bulls
title_sort anti-lipopolysaccharide antibody mitigates ruminal lipopolysaccharide release without acute-phase inflammation or liver transcriptomic responses in holstein bulls
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170223/
https://www.ncbi.nlm.nih.gov/pubmed/34056875
http://dx.doi.org/10.4142/jvs.2021.22.e34
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