Early Improvement of Non-islet Cell Tumor Hypoglycemia by Chemotherapy Using Lenvatinib in a Case with Type 2 Diabetes and Hepatocellular Carcinoma Producing Big IGF-II

A 77-year-old man was treated with a DPP-4 inhibitor for type 2 diabetes. Hypoglycemia occurred frequently, and an examination revealed a tumor with a maximum diameter of 140 mm in both lobes of the liver. Western immunoblotting detected a high-molecular-weight form of insulin-like growth factor-II,...

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Autores principales: Izutsu, Takuma, Ito, Hiroyuki, Fukuda, Izumi, Tamura, Hideki, Matsumoto, Suzuko, Antoku, Shinichi, Mori, Toshiko, Goto, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170237/
https://www.ncbi.nlm.nih.gov/pubmed/33250459
http://dx.doi.org/10.2169/internalmedicine.5328-20
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author Izutsu, Takuma
Ito, Hiroyuki
Fukuda, Izumi
Tamura, Hideki
Matsumoto, Suzuko
Antoku, Shinichi
Mori, Toshiko
Goto, Hiroaki
author_facet Izutsu, Takuma
Ito, Hiroyuki
Fukuda, Izumi
Tamura, Hideki
Matsumoto, Suzuko
Antoku, Shinichi
Mori, Toshiko
Goto, Hiroaki
author_sort Izutsu, Takuma
collection PubMed
description A 77-year-old man was treated with a DPP-4 inhibitor for type 2 diabetes. Hypoglycemia occurred frequently, and an examination revealed a tumor with a maximum diameter of 140 mm in both lobes of the liver. Western immunoblotting detected a high-molecular-weight form of insulin-like growth factor-II, and non-islet cell tumor hypoglycemia was diagnosed. Although prednisolone 40 mg was started, hypoglycemia continued to occur frequently. Surgical tumor removal was not indicated, so lenvatinib was initiated. Hypoglycemia improved quickly, and the tumor shrank until it had partially disappeared. His condition continued to improve, and he was discharged.
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spelling pubmed-81702372021-06-11 Early Improvement of Non-islet Cell Tumor Hypoglycemia by Chemotherapy Using Lenvatinib in a Case with Type 2 Diabetes and Hepatocellular Carcinoma Producing Big IGF-II Izutsu, Takuma Ito, Hiroyuki Fukuda, Izumi Tamura, Hideki Matsumoto, Suzuko Antoku, Shinichi Mori, Toshiko Goto, Hiroaki Intern Med Case Report A 77-year-old man was treated with a DPP-4 inhibitor for type 2 diabetes. Hypoglycemia occurred frequently, and an examination revealed a tumor with a maximum diameter of 140 mm in both lobes of the liver. Western immunoblotting detected a high-molecular-weight form of insulin-like growth factor-II, and non-islet cell tumor hypoglycemia was diagnosed. Although prednisolone 40 mg was started, hypoglycemia continued to occur frequently. Surgical tumor removal was not indicated, so lenvatinib was initiated. Hypoglycemia improved quickly, and the tumor shrank until it had partially disappeared. His condition continued to improve, and he was discharged. The Japanese Society of Internal Medicine 2020-11-30 2021-05-01 /pmc/articles/PMC8170237/ /pubmed/33250459 http://dx.doi.org/10.2169/internalmedicine.5328-20 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Izutsu, Takuma
Ito, Hiroyuki
Fukuda, Izumi
Tamura, Hideki
Matsumoto, Suzuko
Antoku, Shinichi
Mori, Toshiko
Goto, Hiroaki
Early Improvement of Non-islet Cell Tumor Hypoglycemia by Chemotherapy Using Lenvatinib in a Case with Type 2 Diabetes and Hepatocellular Carcinoma Producing Big IGF-II
title Early Improvement of Non-islet Cell Tumor Hypoglycemia by Chemotherapy Using Lenvatinib in a Case with Type 2 Diabetes and Hepatocellular Carcinoma Producing Big IGF-II
title_full Early Improvement of Non-islet Cell Tumor Hypoglycemia by Chemotherapy Using Lenvatinib in a Case with Type 2 Diabetes and Hepatocellular Carcinoma Producing Big IGF-II
title_fullStr Early Improvement of Non-islet Cell Tumor Hypoglycemia by Chemotherapy Using Lenvatinib in a Case with Type 2 Diabetes and Hepatocellular Carcinoma Producing Big IGF-II
title_full_unstemmed Early Improvement of Non-islet Cell Tumor Hypoglycemia by Chemotherapy Using Lenvatinib in a Case with Type 2 Diabetes and Hepatocellular Carcinoma Producing Big IGF-II
title_short Early Improvement of Non-islet Cell Tumor Hypoglycemia by Chemotherapy Using Lenvatinib in a Case with Type 2 Diabetes and Hepatocellular Carcinoma Producing Big IGF-II
title_sort early improvement of non-islet cell tumor hypoglycemia by chemotherapy using lenvatinib in a case with type 2 diabetes and hepatocellular carcinoma producing big igf-ii
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170237/
https://www.ncbi.nlm.nih.gov/pubmed/33250459
http://dx.doi.org/10.2169/internalmedicine.5328-20
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