The Amount of Residual Incretin Regulates the Pancreatic β-cell Function and Glucose Homeostasis

The gastrointestinal tract is considered an important endocrine organ for controlling glucose homeostasis via the production of incretins. A 21-year-old man emergently underwent total colectomy due to severe ulcerative colitis, and overt diabetes became evident. Weekly administration of a glucagon-l...

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Autores principales: Kondo, Tatsuya, Kitano, Sayaka, Miyakawa, Nobukazu, Watanabe, Takuro, Goto, Rieko, Sato, Miki, Hanatani, Satoko, Sakaguchi, Masaji, Igata, Motoyuki, Kawashima, Junji, Motoshima, Hiroyuki, Matsumura, Takeshi, Araki, Eiichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170253/
https://www.ncbi.nlm.nih.gov/pubmed/33952814
http://dx.doi.org/10.2169/internalmedicine.6026-20
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author Kondo, Tatsuya
Kitano, Sayaka
Miyakawa, Nobukazu
Watanabe, Takuro
Goto, Rieko
Sato, Miki
Hanatani, Satoko
Sakaguchi, Masaji
Igata, Motoyuki
Kawashima, Junji
Motoshima, Hiroyuki
Matsumura, Takeshi
Araki, Eiichi
author_facet Kondo, Tatsuya
Kitano, Sayaka
Miyakawa, Nobukazu
Watanabe, Takuro
Goto, Rieko
Sato, Miki
Hanatani, Satoko
Sakaguchi, Masaji
Igata, Motoyuki
Kawashima, Junji
Motoshima, Hiroyuki
Matsumura, Takeshi
Araki, Eiichi
author_sort Kondo, Tatsuya
collection PubMed
description The gastrointestinal tract is considered an important endocrine organ for controlling glucose homeostasis via the production of incretins. A 21-year-old man emergently underwent total colectomy due to severe ulcerative colitis, and overt diabetes became evident. Weekly administration of a glucagon-like peptide (GLP)-1 receptor agonist (RA) dramatically improved his glucose control. Levels of GLP-1 or gastric inhibitory polypeptide (GIP) were low at the baseline in the duodenum and serum of the patient. After 11 months of GLP-1RA treatment, his HbA1c worsened again, and intensive insulin therapy was necessary to control his glucose levels. Our report may explain the significance of residual incretin for maintaining the pancreatic β-cell function.
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spelling pubmed-81702532021-06-11 The Amount of Residual Incretin Regulates the Pancreatic β-cell Function and Glucose Homeostasis Kondo, Tatsuya Kitano, Sayaka Miyakawa, Nobukazu Watanabe, Takuro Goto, Rieko Sato, Miki Hanatani, Satoko Sakaguchi, Masaji Igata, Motoyuki Kawashima, Junji Motoshima, Hiroyuki Matsumura, Takeshi Araki, Eiichi Intern Med Case Report The gastrointestinal tract is considered an important endocrine organ for controlling glucose homeostasis via the production of incretins. A 21-year-old man emergently underwent total colectomy due to severe ulcerative colitis, and overt diabetes became evident. Weekly administration of a glucagon-like peptide (GLP)-1 receptor agonist (RA) dramatically improved his glucose control. Levels of GLP-1 or gastric inhibitory polypeptide (GIP) were low at the baseline in the duodenum and serum of the patient. After 11 months of GLP-1RA treatment, his HbA1c worsened again, and intensive insulin therapy was necessary to control his glucose levels. Our report may explain the significance of residual incretin for maintaining the pancreatic β-cell function. The Japanese Society of Internal Medicine 2021-05-01 2021-05-01 /pmc/articles/PMC8170253/ /pubmed/33952814 http://dx.doi.org/10.2169/internalmedicine.6026-20 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kondo, Tatsuya
Kitano, Sayaka
Miyakawa, Nobukazu
Watanabe, Takuro
Goto, Rieko
Sato, Miki
Hanatani, Satoko
Sakaguchi, Masaji
Igata, Motoyuki
Kawashima, Junji
Motoshima, Hiroyuki
Matsumura, Takeshi
Araki, Eiichi
The Amount of Residual Incretin Regulates the Pancreatic β-cell Function and Glucose Homeostasis
title The Amount of Residual Incretin Regulates the Pancreatic β-cell Function and Glucose Homeostasis
title_full The Amount of Residual Incretin Regulates the Pancreatic β-cell Function and Glucose Homeostasis
title_fullStr The Amount of Residual Incretin Regulates the Pancreatic β-cell Function and Glucose Homeostasis
title_full_unstemmed The Amount of Residual Incretin Regulates the Pancreatic β-cell Function and Glucose Homeostasis
title_short The Amount of Residual Incretin Regulates the Pancreatic β-cell Function and Glucose Homeostasis
title_sort amount of residual incretin regulates the pancreatic β-cell function and glucose homeostasis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170253/
https://www.ncbi.nlm.nih.gov/pubmed/33952814
http://dx.doi.org/10.2169/internalmedicine.6026-20
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