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Therapeutic Potential of TNFα and IL1β Blockade for CRS/ICANS in CAR-T Therapy via Ameliorating Endothelial Activation

Severe cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) strongly hampered the broad clinical applicability of chimeric antigen receptor T cell (CAR-T) therapy. Vascular endothelial activation has been suggested to contribute to the development of CRS...

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Detalles Bibliográficos
Autores principales:	Chen, Yunshuo, Li, Ranran, Shang, Siqi, Yang, Xuejiao, Li, Lei, Wang, Wenbo, Wang, Yueying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170323/ https://www.ncbi.nlm.nih.gov/pubmed/34093519 http://dx.doi.org/10.3389/fimmu.2021.623610

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