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Chicken embryo as a model in epigenetic research
Epigenetics is defined as the study of changes in gene function that are mitotically or meiotically heritable and do not lead to a change in DNA sequence. Epigenetic modifications are important mechanisms that fine tune the expression of genes in response to extracellular signals and environmental c...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170499/ https://www.ncbi.nlm.nih.gov/pubmed/34058565 http://dx.doi.org/10.1016/j.psj.2021.101164 |
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author | Bednarczyk, Marek Dunislawska, Aleksandra Stadnicka, Katarzyna Grochowska, Ewa |
author_facet | Bednarczyk, Marek Dunislawska, Aleksandra Stadnicka, Katarzyna Grochowska, Ewa |
author_sort | Bednarczyk, Marek |
collection | PubMed |
description | Epigenetics is defined as the study of changes in gene function that are mitotically or meiotically heritable and do not lead to a change in DNA sequence. Epigenetic modifications are important mechanisms that fine tune the expression of genes in response to extracellular signals and environmental changes. In vertebrates, crucial epigenetic reprogramming events occur during early embryogenesis and germ cell development. Chicken embryo, which develops external to the mother's body, can be easily manipulated in vivo and in vitro, and hence, it is an excellent model for performing epigenetic studies. Environmental factors such as temperature can affect the development of an embryo into the phenotype of an adult. A better understanding of the environmental impact on embryo development can be achieved by analyzing the direct effects of epigenetic modifications as well as their molecular background and their intergenerational and transgenerational inheritance. In this overview, the current possibility of epigenetic changes during chicken embryonic development and their effects on long-term postembryonic development are discussed. |
format | Online Article Text |
id | pubmed-8170499 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-81704992021-06-09 Chicken embryo as a model in epigenetic research Bednarczyk, Marek Dunislawska, Aleksandra Stadnicka, Katarzyna Grochowska, Ewa Poult Sci GENETICS AND MOLECULAR BIOLOGY Epigenetics is defined as the study of changes in gene function that are mitotically or meiotically heritable and do not lead to a change in DNA sequence. Epigenetic modifications are important mechanisms that fine tune the expression of genes in response to extracellular signals and environmental changes. In vertebrates, crucial epigenetic reprogramming events occur during early embryogenesis and germ cell development. Chicken embryo, which develops external to the mother's body, can be easily manipulated in vivo and in vitro, and hence, it is an excellent model for performing epigenetic studies. Environmental factors such as temperature can affect the development of an embryo into the phenotype of an adult. A better understanding of the environmental impact on embryo development can be achieved by analyzing the direct effects of epigenetic modifications as well as their molecular background and their intergenerational and transgenerational inheritance. In this overview, the current possibility of epigenetic changes during chicken embryonic development and their effects on long-term postembryonic development are discussed. Elsevier 2021-03-26 /pmc/articles/PMC8170499/ /pubmed/34058565 http://dx.doi.org/10.1016/j.psj.2021.101164 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | GENETICS AND MOLECULAR BIOLOGY Bednarczyk, Marek Dunislawska, Aleksandra Stadnicka, Katarzyna Grochowska, Ewa Chicken embryo as a model in epigenetic research |
title | Chicken embryo as a model in epigenetic research |
title_full | Chicken embryo as a model in epigenetic research |
title_fullStr | Chicken embryo as a model in epigenetic research |
title_full_unstemmed | Chicken embryo as a model in epigenetic research |
title_short | Chicken embryo as a model in epigenetic research |
title_sort | chicken embryo as a model in epigenetic research |
topic | GENETICS AND MOLECULAR BIOLOGY |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170499/ https://www.ncbi.nlm.nih.gov/pubmed/34058565 http://dx.doi.org/10.1016/j.psj.2021.101164 |
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