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Chicken embryo as a model in epigenetic research

Epigenetics is defined as the study of changes in gene function that are mitotically or meiotically heritable and do not lead to a change in DNA sequence. Epigenetic modifications are important mechanisms that fine tune the expression of genes in response to extracellular signals and environmental c...

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Autores principales: Bednarczyk, Marek, Dunislawska, Aleksandra, Stadnicka, Katarzyna, Grochowska, Ewa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170499/
https://www.ncbi.nlm.nih.gov/pubmed/34058565
http://dx.doi.org/10.1016/j.psj.2021.101164
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author Bednarczyk, Marek
Dunislawska, Aleksandra
Stadnicka, Katarzyna
Grochowska, Ewa
author_facet Bednarczyk, Marek
Dunislawska, Aleksandra
Stadnicka, Katarzyna
Grochowska, Ewa
author_sort Bednarczyk, Marek
collection PubMed
description Epigenetics is defined as the study of changes in gene function that are mitotically or meiotically heritable and do not lead to a change in DNA sequence. Epigenetic modifications are important mechanisms that fine tune the expression of genes in response to extracellular signals and environmental changes. In vertebrates, crucial epigenetic reprogramming events occur during early embryogenesis and germ cell development. Chicken embryo, which develops external to the mother's body, can be easily manipulated in vivo and in vitro, and hence, it is an excellent model for performing epigenetic studies. Environmental factors such as temperature can affect the development of an embryo into the phenotype of an adult. A better understanding of the environmental impact on embryo development can be achieved by analyzing the direct effects of epigenetic modifications as well as their molecular background and their intergenerational and transgenerational inheritance. In this overview, the current possibility of epigenetic changes during chicken embryonic development and their effects on long-term postembryonic development are discussed.
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spelling pubmed-81704992021-06-09 Chicken embryo as a model in epigenetic research Bednarczyk, Marek Dunislawska, Aleksandra Stadnicka, Katarzyna Grochowska, Ewa Poult Sci GENETICS AND MOLECULAR BIOLOGY Epigenetics is defined as the study of changes in gene function that are mitotically or meiotically heritable and do not lead to a change in DNA sequence. Epigenetic modifications are important mechanisms that fine tune the expression of genes in response to extracellular signals and environmental changes. In vertebrates, crucial epigenetic reprogramming events occur during early embryogenesis and germ cell development. Chicken embryo, which develops external to the mother's body, can be easily manipulated in vivo and in vitro, and hence, it is an excellent model for performing epigenetic studies. Environmental factors such as temperature can affect the development of an embryo into the phenotype of an adult. A better understanding of the environmental impact on embryo development can be achieved by analyzing the direct effects of epigenetic modifications as well as their molecular background and their intergenerational and transgenerational inheritance. In this overview, the current possibility of epigenetic changes during chicken embryonic development and their effects on long-term postembryonic development are discussed. Elsevier 2021-03-26 /pmc/articles/PMC8170499/ /pubmed/34058565 http://dx.doi.org/10.1016/j.psj.2021.101164 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle GENETICS AND MOLECULAR BIOLOGY
Bednarczyk, Marek
Dunislawska, Aleksandra
Stadnicka, Katarzyna
Grochowska, Ewa
Chicken embryo as a model in epigenetic research
title Chicken embryo as a model in epigenetic research
title_full Chicken embryo as a model in epigenetic research
title_fullStr Chicken embryo as a model in epigenetic research
title_full_unstemmed Chicken embryo as a model in epigenetic research
title_short Chicken embryo as a model in epigenetic research
title_sort chicken embryo as a model in epigenetic research
topic GENETICS AND MOLECULAR BIOLOGY
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170499/
https://www.ncbi.nlm.nih.gov/pubmed/34058565
http://dx.doi.org/10.1016/j.psj.2021.101164
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