The role of single-cell sequencing in studying tumour evolution

Tumour evolution is a complex interplay between the acquisition of somatic (epi)genomic changes in tumour cells and the phenotypic consequences they cause, all in the context of a changing microenvironment. Single-cell sequencing offers a window into this dynamic process at the ultimate resolution o...

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Detalles Bibliográficos
Autores principales: Mossner, Maximilian, Baker, Ann-Marie C, Graham, Trevor A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Faculty Opinions Ltd 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170688/
https://www.ncbi.nlm.nih.gov/pubmed/34131659
http://dx.doi.org/10.12703/r/10-49
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author Mossner, Maximilian
Baker, Ann-Marie C
Graham, Trevor A
author_facet Mossner, Maximilian
Baker, Ann-Marie C
Graham, Trevor A
author_sort Mossner, Maximilian
collection PubMed
description Tumour evolution is a complex interplay between the acquisition of somatic (epi)genomic changes in tumour cells and the phenotypic consequences they cause, all in the context of a changing microenvironment. Single-cell sequencing offers a window into this dynamic process at the ultimate resolution of individual cells. In this review, we discuss the transformative insight offered by single-cell sequencing technologies for understanding tumour evolution.
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spelling pubmed-81706882021-06-14 The role of single-cell sequencing in studying tumour evolution Mossner, Maximilian Baker, Ann-Marie C Graham, Trevor A Fac Rev Review Article Tumour evolution is a complex interplay between the acquisition of somatic (epi)genomic changes in tumour cells and the phenotypic consequences they cause, all in the context of a changing microenvironment. Single-cell sequencing offers a window into this dynamic process at the ultimate resolution of individual cells. In this review, we discuss the transformative insight offered by single-cell sequencing technologies for understanding tumour evolution. Faculty Opinions Ltd 2021-05-26 /pmc/articles/PMC8170688/ /pubmed/34131659 http://dx.doi.org/10.12703/r/10-49 Text en Copyright: © 2021 Mossner M et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Mossner, Maximilian
Baker, Ann-Marie C
Graham, Trevor A
The role of single-cell sequencing in studying tumour evolution
title The role of single-cell sequencing in studying tumour evolution
title_full The role of single-cell sequencing in studying tumour evolution
title_fullStr The role of single-cell sequencing in studying tumour evolution
title_full_unstemmed The role of single-cell sequencing in studying tumour evolution
title_short The role of single-cell sequencing in studying tumour evolution
title_sort role of single-cell sequencing in studying tumour evolution
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170688/
https://www.ncbi.nlm.nih.gov/pubmed/34131659
http://dx.doi.org/10.12703/r/10-49
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