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Protective Effects of Descurainia sophia against Gentamicin Induced Nephrotoxicity in Rats
Several studies have tried to find an efficient agent to prevent or reverse gentamicin (Gm) induced acute kidney injury (AKI). In this study, we assessed the potential renal protective effects of Descurainia sophia (L.) Webb ex Prantl against Gm-induced nephrotoxicity in rats. Thirty-five male Wista...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Shaheed Beheshti University of Medical Sciences
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170741/ https://www.ncbi.nlm.nih.gov/pubmed/34400939 http://dx.doi.org/10.22037/ijpr.2020.112105.13535 |
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author | Askari, Hassan Enayati, Noora Ahmadian-Attari, Mohammad Mehdi Bakhtiyari, Mahmood Alirezaei, Amirhesam |
author_facet | Askari, Hassan Enayati, Noora Ahmadian-Attari, Mohammad Mehdi Bakhtiyari, Mahmood Alirezaei, Amirhesam |
author_sort | Askari, Hassan |
collection | PubMed |
description | Several studies have tried to find an efficient agent to prevent or reverse gentamicin (Gm) induced acute kidney injury (AKI). In this study, we assessed the potential renal protective effects of Descurainia sophia (L.) Webb ex Prantl against Gm-induced nephrotoxicity in rats. Thirty-five male Wistar rats were categorized in five groups (n = 7 per group). Control group was treated with normal saline. In four experimental groups, the rats were initially treated with normal saline (A), 800 (B), 1600 (C) and 2400 (D) mg/kg Descurainia sophia respectively for 28 days. After that, the rats of experimental groups were treated with Gm (80 mg/Kg) for 7 consecutive days. Blood and urine markers, as well as apoptosis and histological features were determined. Serum BUN, creatinine, cholesterol, and triglycerides level, as well as urinary excretion of Na(+) significantly increased in group A. Furthermore, Gm induced inflammatory cells infiltration, apoptosis, and renal cells injuries in rats were pretreated with normal saline (group A). However, in the rats pretreated with Descurainia sophia extract (groups B, C, and D, there were significant and dose-dependent reductions in serum BUN, creatinine, cholesterol and triglyceride, urinary Na(+) excretion, apoptosis rate, and inflammatory cells infiltration in renal tissues. Overall, Descurainia sophia showed significant protective effects against Gm-induced AKI by alleviating biochemical and histological markers of renal toxicity. |
format | Online Article Text |
id | pubmed-8170741 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Shaheed Beheshti University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-81707412021-08-15 Protective Effects of Descurainia sophia against Gentamicin Induced Nephrotoxicity in Rats Askari, Hassan Enayati, Noora Ahmadian-Attari, Mohammad Mehdi Bakhtiyari, Mahmood Alirezaei, Amirhesam Iran J Pharm Res Original Article Several studies have tried to find an efficient agent to prevent or reverse gentamicin (Gm) induced acute kidney injury (AKI). In this study, we assessed the potential renal protective effects of Descurainia sophia (L.) Webb ex Prantl against Gm-induced nephrotoxicity in rats. Thirty-five male Wistar rats were categorized in five groups (n = 7 per group). Control group was treated with normal saline. In four experimental groups, the rats were initially treated with normal saline (A), 800 (B), 1600 (C) and 2400 (D) mg/kg Descurainia sophia respectively for 28 days. After that, the rats of experimental groups were treated with Gm (80 mg/Kg) for 7 consecutive days. Blood and urine markers, as well as apoptosis and histological features were determined. Serum BUN, creatinine, cholesterol, and triglycerides level, as well as urinary excretion of Na(+) significantly increased in group A. Furthermore, Gm induced inflammatory cells infiltration, apoptosis, and renal cells injuries in rats were pretreated with normal saline (group A). However, in the rats pretreated with Descurainia sophia extract (groups B, C, and D, there were significant and dose-dependent reductions in serum BUN, creatinine, cholesterol and triglyceride, urinary Na(+) excretion, apoptosis rate, and inflammatory cells infiltration in renal tissues. Overall, Descurainia sophia showed significant protective effects against Gm-induced AKI by alleviating biochemical and histological markers of renal toxicity. Shaheed Beheshti University of Medical Sciences 2021 /pmc/articles/PMC8170741/ /pubmed/34400939 http://dx.doi.org/10.22037/ijpr.2020.112105.13535 Text en https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Askari, Hassan Enayati, Noora Ahmadian-Attari, Mohammad Mehdi Bakhtiyari, Mahmood Alirezaei, Amirhesam Protective Effects of Descurainia sophia against Gentamicin Induced Nephrotoxicity in Rats |
title | Protective Effects of Descurainia sophia against Gentamicin Induced Nephrotoxicity in Rats |
title_full | Protective Effects of Descurainia sophia against Gentamicin Induced Nephrotoxicity in Rats |
title_fullStr | Protective Effects of Descurainia sophia against Gentamicin Induced Nephrotoxicity in Rats |
title_full_unstemmed | Protective Effects of Descurainia sophia against Gentamicin Induced Nephrotoxicity in Rats |
title_short | Protective Effects of Descurainia sophia against Gentamicin Induced Nephrotoxicity in Rats |
title_sort | protective effects of descurainia sophia against gentamicin induced nephrotoxicity in rats |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170741/ https://www.ncbi.nlm.nih.gov/pubmed/34400939 http://dx.doi.org/10.22037/ijpr.2020.112105.13535 |
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