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Less airway inflammation and goblet cell metaplasia in an IL-33-induced asthma model of leptin-deficient obese mice

BACKGROUND: Obesity-associated asthma is a phenotype of severe asthma. Late-onset, non-eosinophilic and female-dominant phenotype is highly symptomatic and difficult to treat. Leptin, an adipokine, exerts an immunomodulatory effect. IL-33 associated with innate immunity induces type 2 inflammation a...

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Detalles Bibliográficos
Autores principales:	Kurokawa, Atsushi, Kondo, Mitsuko, Arimura, Ken, Ashino, Shigeru, Tagaya, Etsuko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170793/ https://www.ncbi.nlm.nih.gov/pubmed/34074279 http://dx.doi.org/10.1186/s12931-021-01763-3

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