Single cell transcriptome revealed tumor associated antigen (TAA) profile in lung adenocarcinoma (LUAD)

It has been suggested that the heterogeneity of TAAs in lung cancer may affect the therapeutic response and disease progression. Up to now, several tumor-associated antigen (TAA)-based cancer vaccines have been investigated in lung adenocarcinoma (LUAD); however, most of them have failed at the stag...

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Detalles Bibliográficos
Autores principales: Lv, Fang, Wu, Xueying, Song, Jin, Wang, Pan, Ren, Shucheng, Guo, Wei, Xue, Qi, Zhang, Henghui, Zhao, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170805/
https://www.ncbi.nlm.nih.gov/pubmed/34074341
http://dx.doi.org/10.1186/s40364-021-00287-8
Descripción
Sumario:It has been suggested that the heterogeneity of TAAs in lung cancer may affect the therapeutic response and disease progression. Up to now, several tumor-associated antigen (TAA)-based cancer vaccines have been investigated in lung adenocarcinoma (LUAD); however, most of them have failed at the stage of clinical trials. The present study suggests that inter-tumoral heterogeneity of TAAs is large at single-cell resolution, while the communication between tumor cells and infiltrating T cells is closely related to the expression profile of TAAs. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40364-021-00287-8.

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