Single cell transcriptome revealed tumor associated antigen (TAA) profile in lung adenocarcinoma (LUAD)

It has been suggested that the heterogeneity of TAAs in lung cancer may affect the therapeutic response and disease progression. Up to now, several tumor-associated antigen (TAA)-based cancer vaccines have been investigated in lung adenocarcinoma (LUAD); however, most of them have failed at the stag...

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Autores principales: Lv, Fang, Wu, Xueying, Song, Jin, Wang, Pan, Ren, Shucheng, Guo, Wei, Xue, Qi, Zhang, Henghui, Zhao, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170805/
https://www.ncbi.nlm.nih.gov/pubmed/34074341
http://dx.doi.org/10.1186/s40364-021-00287-8
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author Lv, Fang
Wu, Xueying
Song, Jin
Wang, Pan
Ren, Shucheng
Guo, Wei
Xue, Qi
Zhang, Henghui
Zhao, Jun
author_facet Lv, Fang
Wu, Xueying
Song, Jin
Wang, Pan
Ren, Shucheng
Guo, Wei
Xue, Qi
Zhang, Henghui
Zhao, Jun
author_sort Lv, Fang
collection PubMed
description It has been suggested that the heterogeneity of TAAs in lung cancer may affect the therapeutic response and disease progression. Up to now, several tumor-associated antigen (TAA)-based cancer vaccines have been investigated in lung adenocarcinoma (LUAD); however, most of them have failed at the stage of clinical trials. The present study suggests that inter-tumoral heterogeneity of TAAs is large at single-cell resolution, while the communication between tumor cells and infiltrating T cells is closely related to the expression profile of TAAs. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40364-021-00287-8.
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spelling pubmed-81708052021-06-02 Single cell transcriptome revealed tumor associated antigen (TAA) profile in lung adenocarcinoma (LUAD) Lv, Fang Wu, Xueying Song, Jin Wang, Pan Ren, Shucheng Guo, Wei Xue, Qi Zhang, Henghui Zhao, Jun Biomark Res Letter to the Editor It has been suggested that the heterogeneity of TAAs in lung cancer may affect the therapeutic response and disease progression. Up to now, several tumor-associated antigen (TAA)-based cancer vaccines have been investigated in lung adenocarcinoma (LUAD); however, most of them have failed at the stage of clinical trials. The present study suggests that inter-tumoral heterogeneity of TAAs is large at single-cell resolution, while the communication between tumor cells and infiltrating T cells is closely related to the expression profile of TAAs. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40364-021-00287-8. BioMed Central 2021-06-02 /pmc/articles/PMC8170805/ /pubmed/34074341 http://dx.doi.org/10.1186/s40364-021-00287-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Letter to the Editor
Lv, Fang
Wu, Xueying
Song, Jin
Wang, Pan
Ren, Shucheng
Guo, Wei
Xue, Qi
Zhang, Henghui
Zhao, Jun
Single cell transcriptome revealed tumor associated antigen (TAA) profile in lung adenocarcinoma (LUAD)
title Single cell transcriptome revealed tumor associated antigen (TAA) profile in lung adenocarcinoma (LUAD)
title_full Single cell transcriptome revealed tumor associated antigen (TAA) profile in lung adenocarcinoma (LUAD)
title_fullStr Single cell transcriptome revealed tumor associated antigen (TAA) profile in lung adenocarcinoma (LUAD)
title_full_unstemmed Single cell transcriptome revealed tumor associated antigen (TAA) profile in lung adenocarcinoma (LUAD)
title_short Single cell transcriptome revealed tumor associated antigen (TAA) profile in lung adenocarcinoma (LUAD)
title_sort single cell transcriptome revealed tumor associated antigen (taa) profile in lung adenocarcinoma (luad)
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170805/
https://www.ncbi.nlm.nih.gov/pubmed/34074341
http://dx.doi.org/10.1186/s40364-021-00287-8
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