Is the mechanism of COVID-19 coagulopathy still a rabbit’s hole?

The pathophysiology of COVID-19 is an enigma with its severity often determined by the extent of coagulopathy. Several regulatory pathways targeted by the SARS-CoV-2 include the renin-angiotensin system, von Willebrand Factor, and most importantly, the complement pathway. This article discusses thes...

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Detalles Bibliográficos
Autores principales: Rajan, Ashna, Thirunavukkarasu, Ganesh Keshav, Lockey, Richard F., Kolliputi, Narasaiah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2021
Materias:
BITS and BYTES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170857/
https://www.ncbi.nlm.nih.gov/pubmed/34076828
http://dx.doi.org/10.1007/s12079-021-00613-7
Descripción
Sumario:The pathophysiology of COVID-19 is an enigma with its severity often determined by the extent of coagulopathy. Several regulatory pathways targeted by the SARS-CoV-2 include the renin-angiotensin system, von Willebrand Factor, and most importantly, the complement pathway. This article discusses these pathways to help design potential future therapies.

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