Cargando…
Genetic and Transcriptomic Biomarkers in Neurodegenerative Diseases: Current Situation and the Road Ahead
Neurodegenerative diseases are etiologically and clinically heterogeneous conditions, often reflecting a spectrum of disease rather than well-defined disorders. The underlying molecular complexity of these diseases has made the discovery and validation of useful biomarkers challenging. The search of...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170880/ https://www.ncbi.nlm.nih.gov/pubmed/33925602 http://dx.doi.org/10.3390/cells10051030 |
_version_ | 1783702325892743168 |
---|---|
author | Lake, Julie Storm, Catherine S. Makarious, Mary B. Bandres-Ciga, Sara |
author_facet | Lake, Julie Storm, Catherine S. Makarious, Mary B. Bandres-Ciga, Sara |
author_sort | Lake, Julie |
collection | PubMed |
description | Neurodegenerative diseases are etiologically and clinically heterogeneous conditions, often reflecting a spectrum of disease rather than well-defined disorders. The underlying molecular complexity of these diseases has made the discovery and validation of useful biomarkers challenging. The search of characteristic genetic and transcriptomic indicators for preclinical disease diagnosis, prognosis, or subtyping is an area of ongoing effort and interest. The next generation of biomarker studies holds promise by implementing meaningful longitudinal and multi-modal approaches in large scale biobank and healthcare system scale datasets. This work will only be possible in an open science framework. This review summarizes the current state of genetic and transcriptomic biomarkers in Parkinson’s disease, Alzheimer’s disease, and amyotrophic lateral sclerosis, providing a comprehensive landscape of recent literature and future directions. |
format | Online Article Text |
id | pubmed-8170880 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81708802021-06-03 Genetic and Transcriptomic Biomarkers in Neurodegenerative Diseases: Current Situation and the Road Ahead Lake, Julie Storm, Catherine S. Makarious, Mary B. Bandres-Ciga, Sara Cells Review Neurodegenerative diseases are etiologically and clinically heterogeneous conditions, often reflecting a spectrum of disease rather than well-defined disorders. The underlying molecular complexity of these diseases has made the discovery and validation of useful biomarkers challenging. The search of characteristic genetic and transcriptomic indicators for preclinical disease diagnosis, prognosis, or subtyping is an area of ongoing effort and interest. The next generation of biomarker studies holds promise by implementing meaningful longitudinal and multi-modal approaches in large scale biobank and healthcare system scale datasets. This work will only be possible in an open science framework. This review summarizes the current state of genetic and transcriptomic biomarkers in Parkinson’s disease, Alzheimer’s disease, and amyotrophic lateral sclerosis, providing a comprehensive landscape of recent literature and future directions. MDPI 2021-04-27 /pmc/articles/PMC8170880/ /pubmed/33925602 http://dx.doi.org/10.3390/cells10051030 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lake, Julie Storm, Catherine S. Makarious, Mary B. Bandres-Ciga, Sara Genetic and Transcriptomic Biomarkers in Neurodegenerative Diseases: Current Situation and the Road Ahead |
title | Genetic and Transcriptomic Biomarkers in Neurodegenerative Diseases: Current Situation and the Road Ahead |
title_full | Genetic and Transcriptomic Biomarkers in Neurodegenerative Diseases: Current Situation and the Road Ahead |
title_fullStr | Genetic and Transcriptomic Biomarkers in Neurodegenerative Diseases: Current Situation and the Road Ahead |
title_full_unstemmed | Genetic and Transcriptomic Biomarkers in Neurodegenerative Diseases: Current Situation and the Road Ahead |
title_short | Genetic and Transcriptomic Biomarkers in Neurodegenerative Diseases: Current Situation and the Road Ahead |
title_sort | genetic and transcriptomic biomarkers in neurodegenerative diseases: current situation and the road ahead |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170880/ https://www.ncbi.nlm.nih.gov/pubmed/33925602 http://dx.doi.org/10.3390/cells10051030 |
work_keys_str_mv | AT lakejulie geneticandtranscriptomicbiomarkersinneurodegenerativediseasescurrentsituationandtheroadahead AT stormcatherines geneticandtranscriptomicbiomarkersinneurodegenerativediseasescurrentsituationandtheroadahead AT makariousmaryb geneticandtranscriptomicbiomarkersinneurodegenerativediseasescurrentsituationandtheroadahead AT bandrescigasara geneticandtranscriptomicbiomarkersinneurodegenerativediseasescurrentsituationandtheroadahead |