Alpha-Synuclein and Mitochondrial Dysfunction in Parkinson’s Disease: The Emerging Role of VDAC

Alpha-Synuclein (αSyn) is a protein whose function is still debated, as well as its role in modulation of mitochondrial function in both physiological and pathological conditions. Mitochondrial porins or Voltage-Dependent Anion Channel (VDAC) proteins are the main gates for ADP/ATP and various subst...

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Autores principales: Risiglione, Pierpaolo, Zinghirino, Federica, Di Rosa, Maria Carmela, Magrì, Andrea, Messina, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170894/
https://www.ncbi.nlm.nih.gov/pubmed/34064816
http://dx.doi.org/10.3390/biom11050718
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author Risiglione, Pierpaolo
Zinghirino, Federica
Di Rosa, Maria Carmela
Magrì, Andrea
Messina, Angela
author_facet Risiglione, Pierpaolo
Zinghirino, Federica
Di Rosa, Maria Carmela
Magrì, Andrea
Messina, Angela
author_sort Risiglione, Pierpaolo
collection PubMed
description Alpha-Synuclein (αSyn) is a protein whose function is still debated, as well as its role in modulation of mitochondrial function in both physiological and pathological conditions. Mitochondrial porins or Voltage-Dependent Anion Channel (VDAC) proteins are the main gates for ADP/ATP and various substrates towards the organelle. Furthermore, they act as a mitochondrial hub for many cytosolic proteins, including αSyn. This review analyzes the main aspects of αSyn-mitochondria interaction, focusing on the role of VDAC and its emerging involvement in the pathological processes.
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spelling pubmed-81708942021-06-03 Alpha-Synuclein and Mitochondrial Dysfunction in Parkinson’s Disease: The Emerging Role of VDAC Risiglione, Pierpaolo Zinghirino, Federica Di Rosa, Maria Carmela Magrì, Andrea Messina, Angela Biomolecules Review Alpha-Synuclein (αSyn) is a protein whose function is still debated, as well as its role in modulation of mitochondrial function in both physiological and pathological conditions. Mitochondrial porins or Voltage-Dependent Anion Channel (VDAC) proteins are the main gates for ADP/ATP and various substrates towards the organelle. Furthermore, they act as a mitochondrial hub for many cytosolic proteins, including αSyn. This review analyzes the main aspects of αSyn-mitochondria interaction, focusing on the role of VDAC and its emerging involvement in the pathological processes. MDPI 2021-05-11 /pmc/articles/PMC8170894/ /pubmed/34064816 http://dx.doi.org/10.3390/biom11050718 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Risiglione, Pierpaolo
Zinghirino, Federica
Di Rosa, Maria Carmela
Magrì, Andrea
Messina, Angela
Alpha-Synuclein and Mitochondrial Dysfunction in Parkinson’s Disease: The Emerging Role of VDAC
title Alpha-Synuclein and Mitochondrial Dysfunction in Parkinson’s Disease: The Emerging Role of VDAC
title_full Alpha-Synuclein and Mitochondrial Dysfunction in Parkinson’s Disease: The Emerging Role of VDAC
title_fullStr Alpha-Synuclein and Mitochondrial Dysfunction in Parkinson’s Disease: The Emerging Role of VDAC
title_full_unstemmed Alpha-Synuclein and Mitochondrial Dysfunction in Parkinson’s Disease: The Emerging Role of VDAC
title_short Alpha-Synuclein and Mitochondrial Dysfunction in Parkinson’s Disease: The Emerging Role of VDAC
title_sort alpha-synuclein and mitochondrial dysfunction in parkinson’s disease: the emerging role of vdac
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170894/
https://www.ncbi.nlm.nih.gov/pubmed/34064816
http://dx.doi.org/10.3390/biom11050718
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