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Prodromal neuroinflammatory, cholinergic and metabolite dysfunction detected by PET and MRS in the TgF344-AD transgenic rat model of AD: a collaborative multi-modal study
Mouse models of Alzheimer's disease (AD) are valuable but do not fully recapitulate human AD pathology, such as spontaneous Tau fibril accumulation and neuronal loss, necessitating the development of new AD models. The transgenic (TG) TgF344-AD rat has been reported to develop age-dependent AD...
Autores principales: | Chaney, Aisling M, Lopez-Picon, Francisco R, Serrière, Sophie, Wang, Rui, Bochicchio, Daniela, Webb, Samuel D, Vandesquille, Matthias, Harte, Michael K, Georgiadou, Christina, Lawrence, Catherine, Busson, Julie, Vercouillie, Johnny, Tauber, Clovis, Buron, Frédéric, Routier, Sylvain, Reekie, Tristan, Snellman, Anniina, Kassiou, Michael, Rokka, Johanna, Davies, Karen E, Rinne, Juha O, Salih, Dervis A, Edwards, Frances A, Orton, Llwyd D, Williams, Stephen R, Chalon, Sylvie, Boutin, Hervé |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8171096/ https://www.ncbi.nlm.nih.gov/pubmed/34093845 http://dx.doi.org/10.7150/thno.56059 |
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