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Infantile mesenchymal hamartoma of the liver with elevated alpha fetoprotein
Mesenchymal hamartoma of the liver (MHL) is a benign tumour that most commonly occurs in children. In most cases of MHL, the α fetoprotein (AFP) level is within the normal limits, only in a few cases, increased AFP has been described which usually causes misdiagnosis of hepatoblastoma. We report a c...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The British Institute of Radiology.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8171140/ https://www.ncbi.nlm.nih.gov/pubmed/34131505 http://dx.doi.org/10.1259/bjrcr.20200196 |
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author | Le, Liem Thanh Phan, Hai Thanh Nguyen, Trung Sao Truong, Khai Dinh Nguyen, Dang Thanh Nguyen, Toan Bao Pham, Thuy Thi Thu |
author_facet | Le, Liem Thanh Phan, Hai Thanh Nguyen, Trung Sao Truong, Khai Dinh Nguyen, Dang Thanh Nguyen, Toan Bao Pham, Thuy Thi Thu |
author_sort | Le, Liem Thanh |
collection | PubMed |
description | Mesenchymal hamartoma of the liver (MHL) is a benign tumour that most commonly occurs in children. In most cases of MHL, the α fetoprotein (AFP) level is within the normal limits, only in a few cases, increased AFP has been described which usually causes misdiagnosis of hepatoblastoma. We report a case of a 3-month-old paediatric patient who was incidentally detected with a very high level of AFP, at 6388.4 ng ml(−1). Ultrasound revealed a right liver tumour, segment VI, measuring at 56 × 53 mm. According to images of ultrasound and MRI, the diagnosis was mesenchymal hepatic sarcoma. The paediatric patient had surgery to remove the entire liver segment containing the tumour. Micropathological examination showed that the tumour was a MHL. The serum AFP level fell rapidly to near normal following the surgery. The MHL benign liver tumour with an atypical presentation caused a very high AFP level. This was a rare clinical case, and it was difficult to diagnose. |
format | Online Article Text |
id | pubmed-8171140 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The British Institute of Radiology. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81711402021-06-14 Infantile mesenchymal hamartoma of the liver with elevated alpha fetoprotein Le, Liem Thanh Phan, Hai Thanh Nguyen, Trung Sao Truong, Khai Dinh Nguyen, Dang Thanh Nguyen, Toan Bao Pham, Thuy Thi Thu BJR Case Rep Case Report Mesenchymal hamartoma of the liver (MHL) is a benign tumour that most commonly occurs in children. In most cases of MHL, the α fetoprotein (AFP) level is within the normal limits, only in a few cases, increased AFP has been described which usually causes misdiagnosis of hepatoblastoma. We report a case of a 3-month-old paediatric patient who was incidentally detected with a very high level of AFP, at 6388.4 ng ml(−1). Ultrasound revealed a right liver tumour, segment VI, measuring at 56 × 53 mm. According to images of ultrasound and MRI, the diagnosis was mesenchymal hepatic sarcoma. The paediatric patient had surgery to remove the entire liver segment containing the tumour. Micropathological examination showed that the tumour was a MHL. The serum AFP level fell rapidly to near normal following the surgery. The MHL benign liver tumour with an atypical presentation caused a very high AFP level. This was a rare clinical case, and it was difficult to diagnose. The British Institute of Radiology. 2021-01-28 /pmc/articles/PMC8171140/ /pubmed/34131505 http://dx.doi.org/10.1259/bjrcr.20200196 Text en © 2021 The Authors. Published by the British Institute of Radiology https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Case Report Le, Liem Thanh Phan, Hai Thanh Nguyen, Trung Sao Truong, Khai Dinh Nguyen, Dang Thanh Nguyen, Toan Bao Pham, Thuy Thi Thu Infantile mesenchymal hamartoma of the liver with elevated alpha fetoprotein |
title | Infantile mesenchymal hamartoma of the liver with elevated alpha fetoprotein |
title_full | Infantile mesenchymal hamartoma of the liver with elevated alpha fetoprotein |
title_fullStr | Infantile mesenchymal hamartoma of the liver with elevated alpha fetoprotein |
title_full_unstemmed | Infantile mesenchymal hamartoma of the liver with elevated alpha fetoprotein |
title_short | Infantile mesenchymal hamartoma of the liver with elevated alpha fetoprotein |
title_sort | infantile mesenchymal hamartoma of the liver with elevated alpha fetoprotein |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8171140/ https://www.ncbi.nlm.nih.gov/pubmed/34131505 http://dx.doi.org/10.1259/bjrcr.20200196 |
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