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Infantile mesenchymal hamartoma of the liver with elevated alpha fetoprotein

Mesenchymal hamartoma of the liver (MHL) is a benign tumour that most commonly occurs in children. In most cases of MHL, the α fetoprotein (AFP) level is within the normal limits, only in a few cases, increased AFP has been described which usually causes misdiagnosis of hepatoblastoma. We report a c...

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Autores principales: Le, Liem Thanh, Phan, Hai Thanh, Nguyen, Trung Sao, Truong, Khai Dinh, Nguyen, Dang Thanh, Nguyen, Toan Bao, Pham, Thuy Thi Thu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The British Institute of Radiology. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8171140/
https://www.ncbi.nlm.nih.gov/pubmed/34131505
http://dx.doi.org/10.1259/bjrcr.20200196
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author Le, Liem Thanh
Phan, Hai Thanh
Nguyen, Trung Sao
Truong, Khai Dinh
Nguyen, Dang Thanh
Nguyen, Toan Bao
Pham, Thuy Thi Thu
author_facet Le, Liem Thanh
Phan, Hai Thanh
Nguyen, Trung Sao
Truong, Khai Dinh
Nguyen, Dang Thanh
Nguyen, Toan Bao
Pham, Thuy Thi Thu
author_sort Le, Liem Thanh
collection PubMed
description Mesenchymal hamartoma of the liver (MHL) is a benign tumour that most commonly occurs in children. In most cases of MHL, the α fetoprotein (AFP) level is within the normal limits, only in a few cases, increased AFP has been described which usually causes misdiagnosis of hepatoblastoma. We report a case of a 3-month-old paediatric patient who was incidentally detected with a very high level of AFP, at 6388.4 ng ml(−1). Ultrasound revealed a right liver tumour, segment VI, measuring at 56 × 53 mm. According to images of ultrasound and MRI, the diagnosis was mesenchymal hepatic sarcoma. The paediatric patient had surgery to remove the entire liver segment containing the tumour. Micropathological examination showed that the tumour was a MHL. The serum AFP level fell rapidly to near normal following the surgery. The MHL benign liver tumour with an atypical presentation caused a very high AFP level. This was a rare clinical case, and it was difficult to diagnose.
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spelling pubmed-81711402021-06-14 Infantile mesenchymal hamartoma of the liver with elevated alpha fetoprotein Le, Liem Thanh Phan, Hai Thanh Nguyen, Trung Sao Truong, Khai Dinh Nguyen, Dang Thanh Nguyen, Toan Bao Pham, Thuy Thi Thu BJR Case Rep Case Report Mesenchymal hamartoma of the liver (MHL) is a benign tumour that most commonly occurs in children. In most cases of MHL, the α fetoprotein (AFP) level is within the normal limits, only in a few cases, increased AFP has been described which usually causes misdiagnosis of hepatoblastoma. We report a case of a 3-month-old paediatric patient who was incidentally detected with a very high level of AFP, at 6388.4 ng ml(−1). Ultrasound revealed a right liver tumour, segment VI, measuring at 56 × 53 mm. According to images of ultrasound and MRI, the diagnosis was mesenchymal hepatic sarcoma. The paediatric patient had surgery to remove the entire liver segment containing the tumour. Micropathological examination showed that the tumour was a MHL. The serum AFP level fell rapidly to near normal following the surgery. The MHL benign liver tumour with an atypical presentation caused a very high AFP level. This was a rare clinical case, and it was difficult to diagnose. The British Institute of Radiology. 2021-01-28 /pmc/articles/PMC8171140/ /pubmed/34131505 http://dx.doi.org/10.1259/bjrcr.20200196 Text en © 2021 The Authors. Published by the British Institute of Radiology https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
spellingShingle Case Report
Le, Liem Thanh
Phan, Hai Thanh
Nguyen, Trung Sao
Truong, Khai Dinh
Nguyen, Dang Thanh
Nguyen, Toan Bao
Pham, Thuy Thi Thu
Infantile mesenchymal hamartoma of the liver with elevated alpha fetoprotein
title Infantile mesenchymal hamartoma of the liver with elevated alpha fetoprotein
title_full Infantile mesenchymal hamartoma of the liver with elevated alpha fetoprotein
title_fullStr Infantile mesenchymal hamartoma of the liver with elevated alpha fetoprotein
title_full_unstemmed Infantile mesenchymal hamartoma of the liver with elevated alpha fetoprotein
title_short Infantile mesenchymal hamartoma of the liver with elevated alpha fetoprotein
title_sort infantile mesenchymal hamartoma of the liver with elevated alpha fetoprotein
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8171140/
https://www.ncbi.nlm.nih.gov/pubmed/34131505
http://dx.doi.org/10.1259/bjrcr.20200196
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