Cargando…

Success rate of microsatellite instability examination and complete response with pembrolizumab in biliary tract cancer

BACKGROUND AND AIM: The success rate of microsatellite instability (MSI) examination in biliary tract cancer (BTC) and the treatment outcomes of pembrolizumab in patients with MSI‐high (MSI‐H) BTC have not been fully investigated. We examined the success rate of MSI examination and the rate of MSI‐H...

Descripción completa

Detalles Bibliográficos
Autores principales: Kai, Yugo, Ikezawa, Kenji, Takada, Ryoji, Daiku, Kazuma, Maeda, Shingo, Abe, Yutaro, Yamai, Takuo, Fukutake, Nobuyasu, Nakabori, Tasuku, Uehara, Hiroyuki, Nagata, Shigenori, Wada, Hiroshi, Ohkawa, Kazuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Publishing Asia Pty Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8171157/
https://www.ncbi.nlm.nih.gov/pubmed/34124390
http://dx.doi.org/10.1002/jgh3.12576
_version_ 1783702378956980224
author Kai, Yugo
Ikezawa, Kenji
Takada, Ryoji
Daiku, Kazuma
Maeda, Shingo
Abe, Yutaro
Yamai, Takuo
Fukutake, Nobuyasu
Nakabori, Tasuku
Uehara, Hiroyuki
Nagata, Shigenori
Wada, Hiroshi
Ohkawa, Kazuyoshi
author_facet Kai, Yugo
Ikezawa, Kenji
Takada, Ryoji
Daiku, Kazuma
Maeda, Shingo
Abe, Yutaro
Yamai, Takuo
Fukutake, Nobuyasu
Nakabori, Tasuku
Uehara, Hiroyuki
Nagata, Shigenori
Wada, Hiroshi
Ohkawa, Kazuyoshi
author_sort Kai, Yugo
collection PubMed
description BACKGROUND AND AIM: The success rate of microsatellite instability (MSI) examination in biliary tract cancer (BTC) and the treatment outcomes of pembrolizumab in patients with MSI‐high (MSI‐H) BTC have not been fully investigated. We examined the success rate of MSI examination and the rate of MSI‐H status in patients with BTC as well as the treatment outcomes of patients with MSI‐H status who underwent pembrolizumab treatment. METHODS: We retrospectively reviewed 60 consecutive patients with unresectable or postoperative recurrent BTC who underwent MSI examination in a Japanese cancer referral center between January 2019 and September 2020. RESULTS: The study included 24 intrahepatic cholangiocarcinomas, 12 hilar cholangiocarcinomas, 4 distal cholangiocarcinomas, 16 gallbladder carcinomas, and 4 ampullary carcinomas. The methods of cancer tissue sampling were percutaneous liver tumor biopsy in 26 cases, surgery in 15 cases, endoscopic ultrasound fine‐needle aspiration in 12 cases, transpapillary bile duct biopsy in 5 cases, and others in 2 cases. The success rate of MSI examination was 98.3% (59 of 60). MSI examination failed in only one case using a surgical specimen due to time‐dependent degradation of DNA. The frequency of MSI‐H BTC was 3.3% (2 of 60 cases). One patient with MSI‐H intrahepatic cholangiocarcinoma achieved a complete response with pembrolizumab treatment. CONCLUSIONS: MSI examinations in BTC were successful in almost all cases, regardless of tissue sampling methods. We experienced a case in which pembrolizumab resulted in a complete response to MSI‐H BTC. Since pembrolizumab for MSI‐H BTC could prolong survival time, MSI examination should be performed proactively to increase treatment options.
format Online
Article
Text
id pubmed-8171157
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Wiley Publishing Asia Pty Ltd
record_format MEDLINE/PubMed
spelling pubmed-81711572021-06-11 Success rate of microsatellite instability examination and complete response with pembrolizumab in biliary tract cancer Kai, Yugo Ikezawa, Kenji Takada, Ryoji Daiku, Kazuma Maeda, Shingo Abe, Yutaro Yamai, Takuo Fukutake, Nobuyasu Nakabori, Tasuku Uehara, Hiroyuki Nagata, Shigenori Wada, Hiroshi Ohkawa, Kazuyoshi JGH Open Original Articles BACKGROUND AND AIM: The success rate of microsatellite instability (MSI) examination in biliary tract cancer (BTC) and the treatment outcomes of pembrolizumab in patients with MSI‐high (MSI‐H) BTC have not been fully investigated. We examined the success rate of MSI examination and the rate of MSI‐H status in patients with BTC as well as the treatment outcomes of patients with MSI‐H status who underwent pembrolizumab treatment. METHODS: We retrospectively reviewed 60 consecutive patients with unresectable or postoperative recurrent BTC who underwent MSI examination in a Japanese cancer referral center between January 2019 and September 2020. RESULTS: The study included 24 intrahepatic cholangiocarcinomas, 12 hilar cholangiocarcinomas, 4 distal cholangiocarcinomas, 16 gallbladder carcinomas, and 4 ampullary carcinomas. The methods of cancer tissue sampling were percutaneous liver tumor biopsy in 26 cases, surgery in 15 cases, endoscopic ultrasound fine‐needle aspiration in 12 cases, transpapillary bile duct biopsy in 5 cases, and others in 2 cases. The success rate of MSI examination was 98.3% (59 of 60). MSI examination failed in only one case using a surgical specimen due to time‐dependent degradation of DNA. The frequency of MSI‐H BTC was 3.3% (2 of 60 cases). One patient with MSI‐H intrahepatic cholangiocarcinoma achieved a complete response with pembrolizumab treatment. CONCLUSIONS: MSI examinations in BTC were successful in almost all cases, regardless of tissue sampling methods. We experienced a case in which pembrolizumab resulted in a complete response to MSI‐H BTC. Since pembrolizumab for MSI‐H BTC could prolong survival time, MSI examination should be performed proactively to increase treatment options. Wiley Publishing Asia Pty Ltd 2021-05-21 /pmc/articles/PMC8171157/ /pubmed/34124390 http://dx.doi.org/10.1002/jgh3.12576 Text en © 2021 The Authors. JGH Open published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Kai, Yugo
Ikezawa, Kenji
Takada, Ryoji
Daiku, Kazuma
Maeda, Shingo
Abe, Yutaro
Yamai, Takuo
Fukutake, Nobuyasu
Nakabori, Tasuku
Uehara, Hiroyuki
Nagata, Shigenori
Wada, Hiroshi
Ohkawa, Kazuyoshi
Success rate of microsatellite instability examination and complete response with pembrolizumab in biliary tract cancer
title Success rate of microsatellite instability examination and complete response with pembrolizumab in biliary tract cancer
title_full Success rate of microsatellite instability examination and complete response with pembrolizumab in biliary tract cancer
title_fullStr Success rate of microsatellite instability examination and complete response with pembrolizumab in biliary tract cancer
title_full_unstemmed Success rate of microsatellite instability examination and complete response with pembrolizumab in biliary tract cancer
title_short Success rate of microsatellite instability examination and complete response with pembrolizumab in biliary tract cancer
title_sort success rate of microsatellite instability examination and complete response with pembrolizumab in biliary tract cancer
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8171157/
https://www.ncbi.nlm.nih.gov/pubmed/34124390
http://dx.doi.org/10.1002/jgh3.12576
work_keys_str_mv AT kaiyugo successrateofmicrosatelliteinstabilityexaminationandcompleteresponsewithpembrolizumabinbiliarytractcancer
AT ikezawakenji successrateofmicrosatelliteinstabilityexaminationandcompleteresponsewithpembrolizumabinbiliarytractcancer
AT takadaryoji successrateofmicrosatelliteinstabilityexaminationandcompleteresponsewithpembrolizumabinbiliarytractcancer
AT daikukazuma successrateofmicrosatelliteinstabilityexaminationandcompleteresponsewithpembrolizumabinbiliarytractcancer
AT maedashingo successrateofmicrosatelliteinstabilityexaminationandcompleteresponsewithpembrolizumabinbiliarytractcancer
AT abeyutaro successrateofmicrosatelliteinstabilityexaminationandcompleteresponsewithpembrolizumabinbiliarytractcancer
AT yamaitakuo successrateofmicrosatelliteinstabilityexaminationandcompleteresponsewithpembrolizumabinbiliarytractcancer
AT fukutakenobuyasu successrateofmicrosatelliteinstabilityexaminationandcompleteresponsewithpembrolizumabinbiliarytractcancer
AT nakaboritasuku successrateofmicrosatelliteinstabilityexaminationandcompleteresponsewithpembrolizumabinbiliarytractcancer
AT ueharahiroyuki successrateofmicrosatelliteinstabilityexaminationandcompleteresponsewithpembrolizumabinbiliarytractcancer
AT nagatashigenori successrateofmicrosatelliteinstabilityexaminationandcompleteresponsewithpembrolizumabinbiliarytractcancer
AT wadahiroshi successrateofmicrosatelliteinstabilityexaminationandcompleteresponsewithpembrolizumabinbiliarytractcancer
AT ohkawakazuyoshi successrateofmicrosatelliteinstabilityexaminationandcompleteresponsewithpembrolizumabinbiliarytractcancer