A Sensitive Whole Blood Assay Detects Antigen-Stimulated Cytokine Release From CD4+ T Cells and Facilitates Immunomonitoring in a Phase 2 Clinical Trial of Nexvax2 in Coeliac Disease

Improved blood tests assessing the functional status of rare gluten-specific CD4+ T cells are needed to effectively monitor experimental therapies for coeliac disease (CD). Our aim was to develop a simple, but highly sensitive cytokine release assay (CRA) for gluten-specific CD4+ T cells that did no...

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Detalles Bibliográficos
Autores principales: Hardy, Melinda Y., Goel, Gautam, Russell, Amy K., Chen Yi Mei, Swee Lin G., Brown, Gregor J. E., Wang, Suyue, Szymczak, Evan, Zhang, Ruan, Goldstein, Kaela E., Neff, Kristin M., Williams, Leslie J., Truitt, Kenneth E., Dzuris, John L., Tye-Din, Jason A., Anderson, Robert P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8171185/
https://www.ncbi.nlm.nih.gov/pubmed/34093551
http://dx.doi.org/10.3389/fimmu.2021.661622

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