Cargando…

Proglucagon-Derived Peptides as Therapeutics

Initially discovered as an impurity in insulin preparations, our understanding of the hyperglycaemic hormone glucagon has evolved markedly over subsequent decades. With description of the precursor proglucagon, we now appreciate that glucagon was just the first proglucagon-derived peptide (PGDP) to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lafferty, Ryan A., O’Harte, Finbarr P. M., Irwin, Nigel, Gault, Victor A., Flatt, Peter R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8171296/ https://www.ncbi.nlm.nih.gov/pubmed/34093449 http://dx.doi.org/10.3389/fendo.2021.689678

Ejemplares similares

Editorial: Proglucagon-Derived Peptides
por: Flatt, Peter R., et al.
Publicado: (2021)

Variation in the Evolution and Sequences of Proglucagon and the Receptors for Proglucagon-Derived Peptides in Mammals
por: Irwin, David M.
Publicado: (2021)

Potential Therapeutic Role for Apelin and Related Peptides in Diabetes: An Update
por: Palmer, Ethan S, et al.
Publicado: (2022)

Mutational Landscape of the Proglucagon-Derived Peptides
por: Lindquist, Peter, et al.
Publicado: (2021)

Sustained glucagon receptor antagonism in insulin-deficient high-fat-fed mice
por: Lafferty, Ryan A, et al.
Publicado: (2022)

Long-term treatment with acylated analogues of apelin-13 amide ameliorates diabetes and improves lipid profile of high-fat fed mice
por: O’Harte, Finbarr P. M., et al.
Publicado: (2018)

A Facile Procedure for One-Pot Stable Conjugation of Two Proglucagon Cysteine-Containing Peptide Analogs
por: He, Rongjun, et al.
Publicado: (2021)

Benefits of Sustained Upregulated Unimolecular GLP-1 and CCK Receptor Signalling in Obesity-Diabetes
por: Tanday, Neil, et al.
Publicado: (2021)

Effects of 2 Novel PYY(1-36) Analogues, (P(3)L(31)P(34))PYY(1-36) and PYY(1-36)(Lys(12)PAL), on Pancreatic Beta-Cell Function, Growth, and Survival
por: Lafferty, Ryan A, et al.
Publicado: (2019)

Postprandial Dynamics of Proglucagon Cleavage Products and Their Relation to Metabolic Health
por: Wagner, Robert, et al.
Publicado: (2022)

The Enigmatic N-Terminal Domain of Proglucagon; A Historical Perspective
por: Conlon, J. Michael
Publicado: (2021)

Heterogeneity of glucagonomas due to differential processing of proglucagon-derived peptides
por: Challis, Benjamin G, et al.
Publicado: (2015)

Glucagon and other proglucagon-derived peptides in the pathogenesis of obesity
por: Holst, Jens Juul
Publicado: (2022)

Positive Effects of NPY1 Receptor Activation on Islet Structure Are Driven by Pancreatic Alpha- and Beta-Cell Transdifferentiation in Diabetic Mice
por: Lafferty, Ryan A., et al.
Publicado: (2021)

Pancreatic Neuroendocrine Tumors in Mice Deficient in Proglucagon-Derived Peptides
por: Takano, Yuko, et al.
Publicado: (2015)

MON-591 Effect of Liraglutide Treatment on Proglucagon-Derived Peptides
por: Kim, Sun, et al.
Publicado: (2020)

Remodeling of Hepatic Metabolism and Hyperaminoacidemia in Mice Deficient in Proglucagon-Derived Peptides
por: Watanabe, Chika, et al.
Publicado: (2012)

Therapeutic Potential of Peptides Derived from Animal Venoms: Current Views and Emerging Drugs for Diabetes
por: Coulter-Parkhill, Aimee, et al.
Publicado: (2021)

Proglucagon-Derived Peptides Expression and Secretion in Rat Insulinoma INS-1 Cells
por: Acosta-Montalvo, Ana, et al.
Publicado: (2020)

A novel neurotensin/xenin fusion peptide enhances β-cell function and exhibits antidiabetic efficacy in high-fat fed mice
por: Perry, Rachele A., et al.
Publicado: (2021)

Beneficial metabolic effects of recurrent periods of beta‐cell rest and stimulation using stable neuropeptide Y1 and glucagon‐like peptide‐1 receptor agonists
por: Tanday, Neil, et al.
Publicado: (2022)

Insights on glicentin, a promising peptide of the proglucagon family
por: Raffort, Juliette, et al.
Publicado: (2017)

Xenin and Related Peptides: Potential Therapeutic Role in Diabetes and Related Metabolic Disorders
por: Craig, Sarah L, et al.
Publicado: (2021)

Fertility and Pregnancy-Associated ß-Cell Proliferation in Mice Deficient in Proglucagon-Derived Peptides
por: Sugiyama, Chisato, et al.
Publicado: (2012)

High Protein Diet Feeding Aggravates Hyperaminoacidemia in Mice Deficient in Proglucagon-Derived Peptides
por: Ueno, Shinji, et al.
Publicado: (2022)

Physicochemical, Nutritional and In Vitro Antidiabetic Characterisation of Blue Whiting (Micromesistius poutassou) Protein Hydrolysates
por: Harnedy-Rothwell, Pádraigín A, et al.
Publicado: (2021)

An enzymatically stable GIP/xenin hybrid peptide restores GIP sensitivity, enhances beta cell function and improves glucose homeostasis in high-fat-fed mice
por: Hasib, Annie, et al.
Publicado: (2016)

The GLP-1 Receptor Agonist Exenatide Ameliorates Bone Composition and Tissue Material Properties in High Fat Fed Diabetic Mice
por: Mansur, Sity Aishah, et al.
Publicado: (2019)

Regulation of intestinal lipid and lipoprotein metabolism by the proglucagon-derived peptides glucagon like peptide 1 and glucagon like peptide 2
por: Mulvihill, Erin E.
Publicado: (2018)

Glucagon induces translocation of glucokinase from the cytoplasm to the nucleus of hepatocytes by transfer between 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase-2 and the glucokinase regulatory protein
por: Cullen, Kirsty S., et al.
Publicado: (2014)

Mice Deficient in Proglucagon-Derived Peptides Exhibit Glucose Intolerance on a High-Fat Diet but Are Resistant to Obesity
por: Takagi, Yusuke, et al.
Publicado: (2015)

Blockade of glucagon increases muscle mass and alters fiber type composition in mice deficient in proglucagon‐derived peptides
por: Ueno, Shinji, et al.
Publicado: (2023)

Biological Activity and Antidiabetic Potential of C-Terminal Octapeptide Fragments of the Gut-Derived Hormone Xenin
por: Martin, Christine M., et al.
Publicado: (2016)

Ectopic Expression of GIP in Pancreatic β-Cells Maintains Enhanced Insulin Secretion in Mice With Complete Absence of Proglucagon-Derived Peptides
por: Fukami, Ayako, et al.
Publicado: (2013)

Metabolic responses and benefits of glucagon‐like peptide‐1 (GLP‐1) receptor ligands
por: Tanday, Neil, et al.
Publicado: (2021)

MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation
por: Zheng, Yuejun, et al.
Publicado: (2023)

Brown adipose tissue thermogenesis in the resistance to and reversal of obesity: A potential new mechanism contributing to the metabolic benefits of proglucagon-derived peptides
por: Lockie, Sarah H, et al.
Publicado: (2013)

Beneficial impact of Ac3IV, an AVP analogue acting specifically at V1a and V1b receptors, on diabetes islet morphology and transdifferentiation of alpha- and beta-cells
por: Mohan, Shruti, et al.
Publicado: (2021)

Aristaless-Related Homeobox Plays a Key Role in Hyperplasia of the Pancreas Islet α–Like Cells in Mice Deficient in Proglucagon-Derived Peptides
por: Xu, Sai, et al.
Publicado: (2013)

Proglucagon peptide secretion profiles in type 2 diabetes before and after bariatric surgery: 1-year prospective study
por: Alexiadou, Kleopatra, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_6ap6h4276l41tr2l2muelh92nq