Phase separation of p53 precedes aggregation and is affected by oncogenic mutations and ligands

Mutant p53 tends to form aggregates with amyloid properties, especially amyloid oligomers inside the nucleus, which are believed to cause oncogenic gain-of-function (GoF). The mechanism of the formation of the aggregates in the nucleus remains uncertain. The present study demonstrated that the DNA-b...

Descripción completa

Detalles Bibliográficos
Autores principales: Petronilho, Elaine C., Pedrote, Murilo M., Marques, Mayra A., Passos, Yulli M., Mota, Michelle F., Jakobus, Benjamin, de Sousa, Gileno dos Santos, Pereira da Costa, Filipe, Felix, Adriani L., Ferretti, Giulia D. S., Almeida, Fernando P., Cordeiro, Yraima, Vieira, Tuane C. R. G., de Oliveira, Guilherme A. P., Silva, Jerson L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8171334/
https://www.ncbi.nlm.nih.gov/pubmed/34163823
http://dx.doi.org/10.1039/d1sc01739j

Ejemplares similares

Ejemplares similares